Changing contact patterns over disease progression: Nipah virus as a case study

Kyu Han Lee; Birgit Nikolay; Hossain M.S. Sazzad; M. Jahangir Hossain; A. K.M.Dawlat Khan; Mahmudur Rahman; Syed Moinuddin Satter; Stuart T. Nichol; John D. Klena; Juliet R.C. Pulliam; A. Marm Kilpatrick; Sharmin Sultana; Sayma Afroj; Peter Daszak; Stephen Luby; Simon Cauchemez; Henrik Salje; Emily S. Gurley

doi:10.1093/infdis/jiaa091

Changing contact patterns over disease progression: Nipah virus as a case study

Kyu Han Lee, Birgit Nikolay, Hossain M.S. Sazzad, M. Jahangir Hossain, A. K.M.Dawlat Khan, Mahmudur Rahman, Syed Moinuddin Satter, Stuart T. Nichol, John D. Klena, Juliet R.C. Pulliam, A. Marm Kilpatrick, Sharmin Sultana, Sayma Afroj, Peter Daszak, Stephen Luby, Simon Cauchemez, Henrik Salje, Emily S. Gurley

Bloomberg School of Public Health

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Contact patterns play a key role in disease transmission, and variation in contacts during the course of illness can influence transmission, particularly when accompanied by changes in host infectiousness. We used surveys among 1642 contacts of 94 Nipah virus case patients in Bangladesh to determine how contact patterns (physical and with bodily fluids) changed as disease progressed in severity. The number of contacts increased with severity and, for case patients who died, peaked on the day of death. Given transmission has only been observed among fatal cases of Nipah virus infection, our findings suggest that changes in contact patterns during illness contribute to risk of infection.

Original language	English (US)
Pages (from-to)	438-442
Number of pages	5
Journal	Journal of Infectious Diseases
Volume	222
Issue number	3
DOIs	https://doi.org/10.1093/infdis/jiaa091
State	Published - Aug 1 2020

Keywords

Infectious disease transmission
Nipah virus
Social behavior

ASJC Scopus subject areas

General Medicine

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10.1093/infdis/jiaa091

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Lee, K. H., Nikolay, B., Sazzad, H. M. S., Hossain, M. J., Khan, A. K. M. D., Rahman, M., Satter, S. M., Nichol, S. T., Klena, J. D., Pulliam, J. R. C., Kilpatrick, A. M., Sultana, S., Afroj, S., Daszak, P., Luby, S., Cauchemez, S., Salje, H., & Gurley, E. S. (2020). Changing contact patterns over disease progression: Nipah virus as a case study. Journal of Infectious Diseases, 222(3), 438-442. https://doi.org/10.1093/infdis/jiaa091

Lee, KH, Nikolay, B, Sazzad, HMS, Hossain, MJ, Khan, AKMD, Rahman, M, Satter, SM, Nichol, ST, Klena, JD, Pulliam, JRC, Kilpatrick, AM, Sultana, S, Afroj, S, Daszak, P, Luby, S, Cauchemez, S, Salje, H & Gurley, ES 2020, 'Changing contact patterns over disease progression: Nipah virus as a case study', Journal of Infectious Diseases, vol. 222, no. 3, pp. 438-442. https://doi.org/10.1093/infdis/jiaa091

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abstract = "Contact patterns play a key role in disease transmission, and variation in contacts during the course of illness can influence transmission, particularly when accompanied by changes in host infectiousness. We used surveys among 1642 contacts of 94 Nipah virus case patients in Bangladesh to determine how contact patterns (physical and with bodily fluids) changed as disease progressed in severity. The number of contacts increased with severity and, for case patients who died, peaked on the day of death. Given transmission has only been observed among fatal cases of Nipah virus infection, our findings suggest that changes in contact patterns during illness contribute to risk of infection.",

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Changing contact patterns over disease progression: Nipah virus as a case study

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