TY - JOUR
T1 - Changing age demographics of inflammatory bowel disease in Ontario, Canada
T2 - A population-based cohort study of epidemiology trends
AU - Benchimol, Eric I.
AU - Manuel, Douglas G.
AU - Guttmann, Astrid
AU - Nguyen, Geoffrey C.
AU - Mojaverian, Nassim
AU - Quach, Pauline
AU - Mack, David R.
N1 - Publisher Copyright:
Copyright © 2014 Crohn's & Colitis Foundation of America, Inc.
PY - 2014/10/1
Y1 - 2014/10/1
N2 - Background: International cohort studies have reported increased incidence of inflammatory bowel disease (IBD) in recent years, and Canada has among the highest rates of IBD in the world. This study assessed incidence and prevalence of IBD in Ontario, the most populous province of Canada, to determine changing trends in age of onset. Methods: We used a population-based cohort derived from validated health administrative data consisting of all Ontario residents living with IBD from 1999 to 2008. We determined trends over time using Poisson regression analysis, assessing rates in 10-year age groups, children, adults, and the elderly. Results: In 2008, 68,071 people were living with IBD among 12,738,350 people (standardized prevalence 534.3 per 100,000 people). Between 1999 and 2008, standardized IBD incidence increased from 21.3 to 26.2 per 100,000 (2.3% per yr, P < 0.0001). Incidence of Crohn's increased from 9.6 to 12.1 per 100,000 (1.9% per yr, P < 0.0001). Ulcerative colitis incidence increased from 10.7 to 12.1 per 100,000 (2.0% per yr, P < 0.0001). For IBD, incidence increased significantly in people younger than 10 years of age (9.7% per yr, P < 0.0001), 10 to 19 years of age (3.8% per yr, P < 0.0001), 30 to 39 years of age (1.8% per yr, P = 0.0006), 40 to 49 years of age (2.8% per yr, P = 0.0001), and 50 to 59 years of age (2.8% per yr, P < 0.0001). Incidence was stable in patients older than 65 years of age at diagnosis (20.1% per yr, P = 0.73). Although incidence did not change significantly over time in adults 20 to 29 years, IBD incidence peaked in this age group. Conclusions: Ontario has among the highest prevalence of IBD in the world. Incidence of IBD increased between 1999 and 2008, owing to increased incidence in children and adults, with stable rates in elderly people. These findings demonstrate the changing age demographics and growing burden of IBD in Ontario, Canada.
AB - Background: International cohort studies have reported increased incidence of inflammatory bowel disease (IBD) in recent years, and Canada has among the highest rates of IBD in the world. This study assessed incidence and prevalence of IBD in Ontario, the most populous province of Canada, to determine changing trends in age of onset. Methods: We used a population-based cohort derived from validated health administrative data consisting of all Ontario residents living with IBD from 1999 to 2008. We determined trends over time using Poisson regression analysis, assessing rates in 10-year age groups, children, adults, and the elderly. Results: In 2008, 68,071 people were living with IBD among 12,738,350 people (standardized prevalence 534.3 per 100,000 people). Between 1999 and 2008, standardized IBD incidence increased from 21.3 to 26.2 per 100,000 (2.3% per yr, P < 0.0001). Incidence of Crohn's increased from 9.6 to 12.1 per 100,000 (1.9% per yr, P < 0.0001). Ulcerative colitis incidence increased from 10.7 to 12.1 per 100,000 (2.0% per yr, P < 0.0001). For IBD, incidence increased significantly in people younger than 10 years of age (9.7% per yr, P < 0.0001), 10 to 19 years of age (3.8% per yr, P < 0.0001), 30 to 39 years of age (1.8% per yr, P = 0.0006), 40 to 49 years of age (2.8% per yr, P = 0.0001), and 50 to 59 years of age (2.8% per yr, P < 0.0001). Incidence was stable in patients older than 65 years of age at diagnosis (20.1% per yr, P = 0.73). Although incidence did not change significantly over time in adults 20 to 29 years, IBD incidence peaked in this age group. Conclusions: Ontario has among the highest prevalence of IBD in the world. Incidence of IBD increased between 1999 and 2008, owing to increased incidence in children and adults, with stable rates in elderly people. These findings demonstrate the changing age demographics and growing burden of IBD in Ontario, Canada.
KW - Crohn's disease
KW - Epidemiology
KW - Health administrative data
KW - Inflammatory bowel disease
KW - Population-based cohort studies
KW - Ulcerative colitis
UR - http://www.scopus.com/inward/record.url?scp=84924444007&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84924444007&partnerID=8YFLogxK
U2 - 10.1097/MIB.0000000000000103
DO - 10.1097/MIB.0000000000000103
M3 - Article
C2 - 25159453
AN - SCOPUS:84924444007
SN - 1078-0998
VL - 20
SP - 1761
EP - 1769
JO - Inflammatory bowel diseases
JF - Inflammatory bowel diseases
IS - 10
ER -