Changes within T cell receptor v(β) subsets in infants following measles vaccination

Paul G. Auwaerter, Gregory D. Hussey, Elizabeth A. Goddard, Jane Hughes, Judith J. Ryon, Peter M. Strebel, David Beatty, Diane E. Griffin

Research output: Contribution to journalArticlepeer-review

Abstract

Measles produces immune suppression which contributes to an increased susceptibility to other infections. Recently, high titered measles vaccines have been linked to increased long-term mortality among some female recipients. Because the mechanisms by which wild-type or attenuated live-vaccine strains of measles virus alter subsequent immune responses are not fully understood, this prompted an examination of the changes within the peripheral blood T cell receptor V(β) repertoire following measles immunization. Twenty-four 6- and 9-month-old infants were studied at 2 weeks and 3 months following immunization by semiquantitative reverse transcription-polymerase chain reaction. There was a significant increase in V(β)2 expression P < 0.05), and a decrease in the V(β)4 subset (P < 0.03) 2 weeks following vaccination with subsequent return to baselines at 3 months in vaccine recipients who seroconverted. These data suggest that measles virus may affect immune responses in part by altering the T cell receptor repertoire.

Original languageEnglish (US)
Pages (from-to)163-170
Number of pages8
JournalClinical Immunology and Immunopathology
Volume79
Issue number2
DOIs
StatePublished - Jan 1 1996

ASJC Scopus subject areas

  • Immunology and Allergy
  • Pathology and Forensic Medicine
  • Immunology

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