Changes within T cell receptor v(β) subsets in infants following measles vaccination

Paul G Auwaerter, Gregory D. Hussey, Elizabeth A. Goddard, Jane Hughes, Judith J. Ryon, Peter M. Strebel, David Beatty, Diane Griffin

Research output: Contribution to journalArticle

Abstract

Measles produces immune suppression which contributes to an increased susceptibility to other infections. Recently, high titered measles vaccines have been linked to increased long-term mortality among some female recipients. Because the mechanisms by which wild-type or attenuated live-vaccine strains of measles virus alter subsequent immune responses are not fully understood, this prompted an examination of the changes within the peripheral blood T cell receptor V(β) repertoire following measles immunization. Twenty-four 6- and 9-month-old infants were studied at 2 weeks and 3 months following immunization by semiquantitative reverse transcription-polymerase chain reaction. There was a significant increase in V(β)2 expression P <0.05), and a decrease in the V(β)4 subset (P <0.03) 2 weeks following vaccination with subsequent return to baselines at 3 months in vaccine recipients who seroconverted. These data suggest that measles virus may affect immune responses in part by altering the T cell receptor repertoire.

Original languageEnglish (US)
Pages (from-to)163-170
Number of pages8
JournalClinical Immunology and Immunopathology
Volume79
Issue number2
DOIs
StatePublished - 1996

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Measles virus
Measles
T-Cell Antigen Receptor
Immunization
Vaccination
Measles Vaccine
Attenuated Vaccines
Reverse Transcription
Blood Cells
Vaccines
Polymerase Chain Reaction
Mortality
Infection

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Pathology and Forensic Medicine

Cite this

Changes within T cell receptor v(β) subsets in infants following measles vaccination. / Auwaerter, Paul G; Hussey, Gregory D.; Goddard, Elizabeth A.; Hughes, Jane; Ryon, Judith J.; Strebel, Peter M.; Beatty, David; Griffin, Diane.

In: Clinical Immunology and Immunopathology, Vol. 79, No. 2, 1996, p. 163-170.

Research output: Contribution to journalArticle

Auwaerter, Paul G ; Hussey, Gregory D. ; Goddard, Elizabeth A. ; Hughes, Jane ; Ryon, Judith J. ; Strebel, Peter M. ; Beatty, David ; Griffin, Diane. / Changes within T cell receptor v(β) subsets in infants following measles vaccination. In: Clinical Immunology and Immunopathology. 1996 ; Vol. 79, No. 2. pp. 163-170.
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