Changes in willingness to participate in HIV vaccine trials among HIV-negative injection drug users

Elizabeth T. Golub; Lisa A. Purvis; Marcella Sapun; Mahboobeh Safaeian; Chris Beyrer; David Vlahov; Steffanie A. Strathdee

doi:10.1007/s10461-005-9004-3

Changes in willingness to participate in HIV vaccine trials among HIV-negative injection drug users

Elizabeth T. Golub, Lisa A. Purvis, Marcella Sapun, Mahboobeh Safaeian, Chris Beyrer, David Vlahov, Steffanie A. Strathdee

Bloomberg School of Public Health

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Abstract

Injection drug users (IDUs) represent an important risk group for HIV infection. We assessed correlates of IDUs' willingness to participate (WTP) in HIV vaccine trials, and examined temporal changes in WTP. Participants were enrolled in ALIVE, a prospective study of HIV among IDUs in Baltimore; semi-annual visits include interviews and HIV serology. Questionnaires regarding WTP were administered in 1993-1994 and again in 2001-2002. Logistic regression was conducted to identify correlates of WTP. Wave 1 of the survey included 440 participants; Wave 2 included 582 participants (189 participated in both waves). WTP increased modestly over time (83.4 vs. 86.3%; p = 0.16). Monetary incentives were the strongest predictor of WTP (adjOR = 2.73; 95% CI: 1.72-4.35). High expectations of HIV treatment effectiveness did not predict WTP. In this cohort, WTP remained strong and modestly increased over the study period. These results should be considered in the planning of sampling and retention strategies for future vaccine trials.

Original language	English (US)
Pages (from-to)	301-309
Number of pages	9
Journal	AIDS and behavior
Volume	9
Issue number	3
DOIs	https://doi.org/10.1007/s10461-005-9004-3
State	Published - Sep 2005

Keywords

HIV
Injection drug users
Vaccine
Willingness

ASJC Scopus subject areas

Social Psychology
Public Health, Environmental and Occupational Health
Infectious Diseases

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10.1007/s10461-005-9004-3

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title = "Changes in willingness to participate in HIV vaccine trials among HIV-negative injection drug users",

abstract = "Injection drug users (IDUs) represent an important risk group for HIV infection. We assessed correlates of IDUs' willingness to participate (WTP) in HIV vaccine trials, and examined temporal changes in WTP. Participants were enrolled in ALIVE, a prospective study of HIV among IDUs in Baltimore; semi-annual visits include interviews and HIV serology. Questionnaires regarding WTP were administered in 1993-1994 and again in 2001-2002. Logistic regression was conducted to identify correlates of WTP. Wave 1 of the survey included 440 participants; Wave 2 included 582 participants (189 participated in both waves). WTP increased modestly over time (83.4 vs. 86.3%; p = 0.16). Monetary incentives were the strongest predictor of WTP (adjOR = 2.73; 95% CI: 1.72-4.35). High expectations of HIV treatment effectiveness did not predict WTP. In this cohort, WTP remained strong and modestly increased over the study period. These results should be considered in the planning of sampling and retention strategies for future vaccine trials.",

keywords = "HIV, Injection drug users, Vaccine, Willingness",

author = "Golub, {Elizabeth T.} and Purvis, {Lisa A.} and Marcella Sapun and Mahboobeh Safaeian and Chris Beyrer and David Vlahov and Strathdee, {Steffanie A.}",

note = "Funding Information: This study was supported by grants from the National Institute of Drug Abuse, National Institutes of Health, Washington, DC, USA (DA 04334; DA 05911; DA 12568). The authors wish to express their appreciation to the ALIVE staff and participants, the staff of the Johns Hopkins Bloomberg School of Public Health Center for Immunization Research, and the HIV Vaccine Trial Network.",

year = "2005",

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doi = "10.1007/s10461-005-9004-3",

language = "English (US)",

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T1 - Changes in willingness to participate in HIV vaccine trials among HIV-negative injection drug users

AU - Golub, Elizabeth T.

AU - Purvis, Lisa A.

AU - Sapun, Marcella

AU - Safaeian, Mahboobeh

AU - Beyrer, Chris

AU - Vlahov, David

AU - Strathdee, Steffanie A.

N1 - Funding Information: This study was supported by grants from the National Institute of Drug Abuse, National Institutes of Health, Washington, DC, USA (DA 04334; DA 05911; DA 12568). The authors wish to express their appreciation to the ALIVE staff and participants, the staff of the Johns Hopkins Bloomberg School of Public Health Center for Immunization Research, and the HIV Vaccine Trial Network.

PY - 2005/9

Y1 - 2005/9

N2 - Injection drug users (IDUs) represent an important risk group for HIV infection. We assessed correlates of IDUs' willingness to participate (WTP) in HIV vaccine trials, and examined temporal changes in WTP. Participants were enrolled in ALIVE, a prospective study of HIV among IDUs in Baltimore; semi-annual visits include interviews and HIV serology. Questionnaires regarding WTP were administered in 1993-1994 and again in 2001-2002. Logistic regression was conducted to identify correlates of WTP. Wave 1 of the survey included 440 participants; Wave 2 included 582 participants (189 participated in both waves). WTP increased modestly over time (83.4 vs. 86.3%; p = 0.16). Monetary incentives were the strongest predictor of WTP (adjOR = 2.73; 95% CI: 1.72-4.35). High expectations of HIV treatment effectiveness did not predict WTP. In this cohort, WTP remained strong and modestly increased over the study period. These results should be considered in the planning of sampling and retention strategies for future vaccine trials.

AB - Injection drug users (IDUs) represent an important risk group for HIV infection. We assessed correlates of IDUs' willingness to participate (WTP) in HIV vaccine trials, and examined temporal changes in WTP. Participants were enrolled in ALIVE, a prospective study of HIV among IDUs in Baltimore; semi-annual visits include interviews and HIV serology. Questionnaires regarding WTP were administered in 1993-1994 and again in 2001-2002. Logistic regression was conducted to identify correlates of WTP. Wave 1 of the survey included 440 participants; Wave 2 included 582 participants (189 participated in both waves). WTP increased modestly over time (83.4 vs. 86.3%; p = 0.16). Monetary incentives were the strongest predictor of WTP (adjOR = 2.73; 95% CI: 1.72-4.35). High expectations of HIV treatment effectiveness did not predict WTP. In this cohort, WTP remained strong and modestly increased over the study period. These results should be considered in the planning of sampling and retention strategies for future vaccine trials.

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Changes in willingness to participate in HIV vaccine trials among HIV-negative injection drug users

Abstract

Keywords

ASJC Scopus subject areas

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