Changes in tuberculin skin test positivity over 20 years in periurban shantytowns in Lima, Peru

Leonardo Martinez, Alyssa Arman, Nathan Haveman, Ashley Lundgren, Lilia Cabrera, Carlton A. Evans, Tom F. Pelly, Mayuko Saito, David Callacondo, Richard Oberhelman, Gisela Collazo, Andrés M. Carnero, Robert H. Gilman

Research output: Contribution to journalArticle

Abstract

A cross-sectional, community-based study was performed in 2012 with 428 residents of periurban shantytowns in Lima, Peru to study risk factors for and changes in latent tuberculosis infection in age-stratified groups compared with our data from the same region in 1990 (N = 219) and 2005 (N = 103). Tuberculin skin test positivity in these communities was highly prevalent at 52% overall, increased with age (P < 0.01) and was similar to 2005 (53%) and 1990 (48%). From 1990 to 2012, the prevalence of tuberculin positivity decreased in 5-14 and 15-24 year old groups (to 17%and 34%, respectively, both P < 0.05). However, this may be explained by cessation of Bacille Calmette-Guérin revaccination during this period, because Bacille Calmette-Guérin revaccination doubled tuberculin positivity. Over the same 22-year period, tuberculin positivity in the 25 year old group remained high (71%, P = 0.3), suggesting that prevalent latent tuberculosis infection persists in the adult population despite improving medical care and socioeconomic development in this region.

Original languageEnglish (US)
Pages (from-to)507-515
Number of pages9
JournalAmerican Journal of Tropical Medicine and Hygiene
Volume89
Issue number3
DOIs
StatePublished - Sep 2013

ASJC Scopus subject areas

  • Parasitology
  • Virology
  • Infectious Diseases

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    Martinez, L., Arman, A., Haveman, N., Lundgren, A., Cabrera, L., Evans, C. A., Pelly, T. F., Saito, M., Callacondo, D., Oberhelman, R., Collazo, G., Carnero, A. M., & Gilman, R. H. (2013). Changes in tuberculin skin test positivity over 20 years in periurban shantytowns in Lima, Peru. American Journal of Tropical Medicine and Hygiene, 89(3), 507-515. https://doi.org/10.4269/ajtmh.13-0005