@article{d0897b635e6c4d46b1de10e5868ff190,
title = "Changes in the microbiota cause genetically modified Anopheles to spread in a population",
abstract = "The mosquito{\textquoteright}s innate immune system controls both Plasmodium and bacterial infections. We investigated the competitiveness of mosquitoes genetically modified to alter expression of their own anti-Plasmodium immune genes in a mixed-cage population with wild-type mosquitoes. We observed that genetically modified mosquitoes with increased immune activity in the midgut tissue did not have an observed fitness disadvantage and showed reduced microbial loads in both the midgut and reproductive organs. These changes result in a mating preference of genetically modified males for wild-type females, whereas wild-type males prefer genetically modified females. These changes foster the spread of the genetic modification in a mosquito cage population.",
author = "Andrew Pike and Yuemei Dong and Dizaji, {Nahid Borhani} and Anthony Gacita and Mongodin, {Emmanuel F.} and George Dimopoulos",
note = "Funding Information: This work was supported by NIH/National Institute of Allergy and Infectious Diseases grant RO1AI061576 and a Johns Hopkins Malaria Research Institute (JHMRI) predoctoral fellowship (to A.P.). We thank the JHMRI Insectary and Parasitology core facilities and D. McClellan for editorial assistance. We also thank Bloomberg Philanthropies for support. Additional data can be found in the supplementary materials. 16S sequencing and sample metadata generated for all 40 samples have been deposited in the Sequence Read Archive (SRA) database under BioProject PRJNA397763 and SRA accession number SRP115247. Publisher Copyright: {\textcopyright} 2017, American Association for the Advancement of Science. All rights reserved.",
year = "2017",
month = sep,
day = "29",
doi = "10.1126/science.aak9691",
language = "English (US)",
volume = "357",
pages = "1396--1399",
journal = "Science",
issn = "0036-8075",
publisher = "American Association for the Advancement of Science",
number = "6358",
}