Changes in systolic blood pressure associated with lead in blood and bone

Barbara S. Glenn, Karen J Bandeen Roche, Byung Kook Lee, Virginia Marie Weaver, Andrew C. Todd, Brian S Schwartz

Research output: Contribution to journalArticle

Abstract

BACKGROUND: Several studies have examined longitudinal associations of blood pressure change or hypertension incidence with lead concentration in blood or bone. It is not clear whether the observed associations reflect an immediate response to lead as a consequence of recent dose or rather are a persistent effect of cumulative dose over a lifetime. METHODS: We followed 575 subjects in a lead-exposed occupational cohort in South Korea between October 1997 and June 2001. We used generalized estimating equation models to evaluate blood pressure change between study visits in relation to tibia lead concentrations at each prior visit and concurrent changes in blood lead. The modeling strategy summarized the longitudinal association of blood pressure with cumulative lead dose or changes in recent lead dose. RESULTS: On average, participants were 41 years old at baseline and had worked 8.5 years in lead-exposed jobs. At baseline, the average ± standard deviation for blood lead was 31.4 ± 14.2 μg/dL, and for tibia lead, it was 38.4 ± 42.9 μg/g bone mineral. Change in systolic blood pressure during the study was associated with concurrent blood lead change, with an average annual increase of 0.9 (95% confidence interval = 0.1 to 1.6) mm Hg for every 10-μg/dL increase in blood lead per year. CONCLUSION: The findings in this relatively young population of current and former lead workers suggest that systolic blood pressure responds to lead dose through acute pathways in addition to the effects of cumulative injury.

Original languageEnglish (US)
Pages (from-to)538-544
Number of pages7
JournalEpidemiology
Volume17
Issue number5
DOIs
StatePublished - Sep 2006

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Blood Pressure
Bone and Bones
Tibia
Lead
Republic of Korea
Minerals
Confidence Intervals
Hypertension
Incidence
Wounds and Injuries
Population

ASJC Scopus subject areas

  • Epidemiology

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Changes in systolic blood pressure associated with lead in blood and bone. / Glenn, Barbara S.; Bandeen Roche, Karen J; Lee, Byung Kook; Weaver, Virginia Marie; Todd, Andrew C.; Schwartz, Brian S.

In: Epidemiology, Vol. 17, No. 5, 09.2006, p. 538-544.

Research output: Contribution to journalArticle

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