Changes in surface expression of platelet membrane glycoproteins and progression of heart transplant vasculopathy

Suzanne Fateh-Moghadam, Wolfgang Bocksch, Andreas Ruf, Timm Dickfeld, Michael Schartl, Gisela Pogátsa-Murray, Roland Hetzer, Eckart Fleck, Meinrad Gawaz

Research output: Contribution to journalArticlepeer-review

Abstract

Background - Transplant vasculopathy is the main limiting factor of the long-term success of heart transplantation. We sought to establish the role of platelets in the development and progression of transplant vasculopathy. Methods and Results - Platelet analysis and intracoronary ultrasound examination were performed in 78 heart transplant recipients. Quantitative intracoronary ultrasound was used to define the severity of disease at baseline (48.8±4.5 months after transplantation) and at 1-year follow-up. Platelet activation was assessed with the use of immunological surface markers of activation (ligand-induced binding site 1 [LIBS-1], P-selectin, GPIIb-IIIa) and flow cytometry. We found thai LIBS-1 immunoreactivity was significantly increased in patients with diffuse disease when compared with focal transplant disease (median [quartile], 27[14, 64] versus 18[7.9, 47], P=0.04). In a logistic regression model, we found that LIBS-1 was an independent predictor for the presence and progression of diffuse transplant vasculopathy (P=0.04). Patients with enhanced LIBS-1 levels (>75% quartile) had a 3,3-fold increased relative risk (95% CI1.8 and 18.9, P=0.002) for the presence of diffuse transplant vasculopathy. When a cutoff value of 16.5 for the level of LIBS-1 was used, patients had a4.8-fold increased relative risk (95% CI 1.9 and 12.5, P

Original languageEnglish (US)
Pages (from-to)890-897
Number of pages8
JournalCirculation
Volume102
Issue number8
StatePublished - Aug 22 2000
Externally publishedYes

Keywords

  • Glycoproteins
  • Platelets
  • Transplantation
  • Vasculature

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

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