Changes in [18F]Fluorodeoxyglucose Activities in a Shockwave-Induced Traumatic Brain Injury Model Using Lithotripsy

Afshin A. Divani, Jenny Ann Phan, Pascal Salazar, Karen S. Santacruz, Ornina Bachour, Javad Mahmoudi, Xiao Hong Zhu, Martin Gilbert Pomper

Research output: Contribution to journalArticle

Abstract

We present a longitudinal study of cerebral metabolism using [18F]fluorodeoxyglucose (FDG) positron emission tomography (PET) in a rat model of shockwave-induced traumatic brain injury (SW-TBI). Anesthetized rats received 5 or 10 SW pulses to the right anterior lateral or dorsal frontal regions using SW lithotripsy. Animals were scanned for FDG uptake at baseline, 3 h post-injury, and 3 days post-injury, using a small animal PET/computed tomography (CT) scanner. FDG uptake at all time-points was quantified as the ratio of brain activity relative to peripheral activity in the left ventricle (LV) in the heart (Abrain/ALV) for the entire brain, each hemisphere, and four cortices (motor, cingulate, somatosensory, and retrosplenial). The mixed-designed models analysis of variance (ANOVA) for the hemispheric and global FDG uptake ratio showed a significant effect of the time-of-scan (p = 0.038) and measured region (p = 6.12e-09). We also observed a significant effect of the time-of-scan (p = 0.046) and measured region (p = 2.28e-09) for the FDG uptake ratio in four cortical regions. None of the measurements (global or local) showed a significant effect for the number of SW pulses (5 or 10) or SW location (lateral or dorsal frontal regions). Our data suggest that SW-TBI causes hypermetabolism on the impact side of the rat brain at 3 h post-injury compared with the baseline measurements. However, the increase in FDG uptake by day 3 post-injury was not significant. Further studies on post-TBI metabolic changes are needed to understand better the pathophysiology of the injury.

Original languageEnglish (US)
Pages (from-to)187-194
Number of pages8
JournalJournal of Neurotrauma
Volume35
Issue number1
DOIs
StatePublished - Jan 1 2018

Fingerprint

Lithotripsy
Fluorodeoxyglucose F18
Wounds and Injuries
Brain
X-Ray Computed Tomography Scanners
Gyrus Cinguli
Motor Cortex
Positron-Emission Tomography
Heart Ventricles
Longitudinal Studies
Analysis of Variance
Traumatic Brain Injury

Keywords

  • blast traumatic brain injury
  • cerebral metabolism
  • FDG
  • head injury
  • lithotripsy
  • PET
  • shockwave

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

Changes in [18F]Fluorodeoxyglucose Activities in a Shockwave-Induced Traumatic Brain Injury Model Using Lithotripsy. / Divani, Afshin A.; Phan, Jenny Ann; Salazar, Pascal; Santacruz, Karen S.; Bachour, Ornina; Mahmoudi, Javad; Zhu, Xiao Hong; Pomper, Martin Gilbert.

In: Journal of Neurotrauma, Vol. 35, No. 1, 01.01.2018, p. 187-194.

Research output: Contribution to journalArticle

Divani, Afshin A. ; Phan, Jenny Ann ; Salazar, Pascal ; Santacruz, Karen S. ; Bachour, Ornina ; Mahmoudi, Javad ; Zhu, Xiao Hong ; Pomper, Martin Gilbert. / Changes in [18F]Fluorodeoxyglucose Activities in a Shockwave-Induced Traumatic Brain Injury Model Using Lithotripsy. In: Journal of Neurotrauma. 2018 ; Vol. 35, No. 1. pp. 187-194.
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