Changes in Serum Creatine Phosphokinase Activity: Following Thoracic, Cardiac, and Abdominal Operations

Sewell H. Dixon, James C A Fuchs, Paul A. Ebert

Research output: Contribution to journalArticle

Abstract

There is an increased necessity of interest in the recognition of acute myocardial infarction (AMI) occurring during operation or in the early postoperative period. Measurement of serum creatine phosphokinase (SCPK) activity has proven to be useful in the diagnosis and verification of AMI in nonsurgical patients. Fifty-eight patients undergoing thoracic, cardiac, and abdominal operations were studied with preoperative and serial postoperative determinations of SCPK. A marked rise in SCPK activity, related to tissue trauma and injury, occurred postoperatively with the maximal level recorded at 24 to 48 hours after operation, followed by a decline toward normal in five days. Three patients suffered acute myocardial infarctions and had an increased magnitude and duration of SCPK elevation. The results of this study define the pattern of postoperative SCPK activity that normally can be expected, and provide information that may be useful in the recognition of postoperative AMI.

Original languageEnglish (US)
Pages (from-to)66-68
Number of pages3
JournalArchives of Surgery
Volume103
Issue number1
DOIs
StatePublished - 1971
Externally publishedYes

Fingerprint

Creatine Kinase
Thorax
Myocardial Infarction
Serum
Wounds and Injuries
Postoperative Period

ASJC Scopus subject areas

  • Surgery

Cite this

Changes in Serum Creatine Phosphokinase Activity : Following Thoracic, Cardiac, and Abdominal Operations. / Dixon, Sewell H.; Fuchs, James C A; Ebert, Paul A.

In: Archives of Surgery, Vol. 103, No. 1, 1971, p. 66-68.

Research output: Contribution to journalArticle

Dixon, Sewell H. ; Fuchs, James C A ; Ebert, Paul A. / Changes in Serum Creatine Phosphokinase Activity : Following Thoracic, Cardiac, and Abdominal Operations. In: Archives of Surgery. 1971 ; Vol. 103, No. 1. pp. 66-68.
@article{d9768ecff8b5465fa9539df1b81642bd,
title = "Changes in Serum Creatine Phosphokinase Activity: Following Thoracic, Cardiac, and Abdominal Operations",
abstract = "There is an increased necessity of interest in the recognition of acute myocardial infarction (AMI) occurring during operation or in the early postoperative period. Measurement of serum creatine phosphokinase (SCPK) activity has proven to be useful in the diagnosis and verification of AMI in nonsurgical patients. Fifty-eight patients undergoing thoracic, cardiac, and abdominal operations were studied with preoperative and serial postoperative determinations of SCPK. A marked rise in SCPK activity, related to tissue trauma and injury, occurred postoperatively with the maximal level recorded at 24 to 48 hours after operation, followed by a decline toward normal in five days. Three patients suffered acute myocardial infarctions and had an increased magnitude and duration of SCPK elevation. The results of this study define the pattern of postoperative SCPK activity that normally can be expected, and provide information that may be useful in the recognition of postoperative AMI.",
author = "Dixon, {Sewell H.} and Fuchs, {James C A} and Ebert, {Paul A.}",
year = "1971",
doi = "10.1001/archsurg.1971.01350070092021",
language = "English (US)",
volume = "103",
pages = "66--68",
journal = "JAMA Surgery",
issn = "2168-6254",
publisher = "American Medical Association",
number = "1",

}

TY - JOUR

T1 - Changes in Serum Creatine Phosphokinase Activity

T2 - Following Thoracic, Cardiac, and Abdominal Operations

AU - Dixon, Sewell H.

AU - Fuchs, James C A

AU - Ebert, Paul A.

PY - 1971

Y1 - 1971

N2 - There is an increased necessity of interest in the recognition of acute myocardial infarction (AMI) occurring during operation or in the early postoperative period. Measurement of serum creatine phosphokinase (SCPK) activity has proven to be useful in the diagnosis and verification of AMI in nonsurgical patients. Fifty-eight patients undergoing thoracic, cardiac, and abdominal operations were studied with preoperative and serial postoperative determinations of SCPK. A marked rise in SCPK activity, related to tissue trauma and injury, occurred postoperatively with the maximal level recorded at 24 to 48 hours after operation, followed by a decline toward normal in five days. Three patients suffered acute myocardial infarctions and had an increased magnitude and duration of SCPK elevation. The results of this study define the pattern of postoperative SCPK activity that normally can be expected, and provide information that may be useful in the recognition of postoperative AMI.

AB - There is an increased necessity of interest in the recognition of acute myocardial infarction (AMI) occurring during operation or in the early postoperative period. Measurement of serum creatine phosphokinase (SCPK) activity has proven to be useful in the diagnosis and verification of AMI in nonsurgical patients. Fifty-eight patients undergoing thoracic, cardiac, and abdominal operations were studied with preoperative and serial postoperative determinations of SCPK. A marked rise in SCPK activity, related to tissue trauma and injury, occurred postoperatively with the maximal level recorded at 24 to 48 hours after operation, followed by a decline toward normal in five days. Three patients suffered acute myocardial infarctions and had an increased magnitude and duration of SCPK elevation. The results of this study define the pattern of postoperative SCPK activity that normally can be expected, and provide information that may be useful in the recognition of postoperative AMI.

UR - http://www.scopus.com/inward/record.url?scp=0015094715&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0015094715&partnerID=8YFLogxK

U2 - 10.1001/archsurg.1971.01350070092021

DO - 10.1001/archsurg.1971.01350070092021

M3 - Article

C2 - 5088433

AN - SCOPUS:0015094715

VL - 103

SP - 66

EP - 68

JO - JAMA Surgery

JF - JAMA Surgery

SN - 2168-6254

IS - 1

ER -