@article{a6ac7967754a410db68ff717d26d2cb7,
title = "Changes in pairwise functional connectivity associated with changes in cognitive performance in cognitively normal older individuals: A two-year observational study",
abstract = "Neurobiological substrates of cognitive decline in cognitively normal older individuals have been investigated by resting-state functional magnetic resonance imaging, but little is known about the relationship between longitudinal changes in the whole brain. In this study, we examined two-year changes in functional connectivity among 80 gray matter areas and investigated the relationship to two-year changes in cognitive performance. A cross-validated permutation variable importance measure was applied to select features related to a change in cognitive performance. Age-corrected changes in eleven pairs of functional connections were selected as important features, all related to brain areas that belong to the default mode network. A linear regression model with cross-validation demonstrated a mean correlation coefficient of 0.55 between measured and predicted changes in the cognitive composite score. These results suggest that intra- and inter-network connections in the default mode network are associated with cognitive changes over two years among cognitively normal individuals.",
keywords = "Cognitive change, Cognitively normal, Default mode network, Resting-state functional magnetic resonance imaging, Salience network",
author = "{the BIOCARD Research Team} and Kumiko Oishi and Anja Soldan and Corinne Pettigrew and Johnny Hsu and Susumu Mori and Marilyn Albert and Kenichi Oishi",
note = "Funding Information: This study is supported by grants from the National Institutes of Health: 5U19-AG0336555 and R01NS084957. The BIOCARD Study consists of seven Cores with the following members: (1) the Administrative Core (MA and Rostislav Brichko); (2) the Clinical Core (MA, AS, CP, Rebecca Gottesman, Ned Sacktor, Scott Turner, Leonie Farrington, Maura Grega, Gay Rudow, Daniel D{\textquoteright}Agostino, and Scott Rudow); (3) the Imaging Core (MM, Susumu Mori, Tilak Ratnanather, Timothy Brown, Hayan Chi, Anthony Kolasny, Kenichi Oishi, and Laurent Younes); (4) the Biospecimen Core (AM and Richard O{\textquoteright}Brien); (5) the Informatics Core (Roberta Scherer, David Shade, Ann Ervin, Jennifer Jones, Hamadou Coulibaly, and April Patterson); (6) the Biostatistics Core (Mei-Cheng Wang, Daisy Zhu, and Jiangxia Wang); and (7) the Neuropathology Core (Juan Troncoso, Olga Pletnikova, Gay Rudow, and Karen Fisher). The authors are grateful to the members of the BIOCARD Scientific Advisory Board who provided continued oversight and guidance regarding the conduct of the study, including Drs. John Csernansky, David Holtzman, David Knopman, Walter Kukull, and Kevin Grimm, and Drs. John Hsiao and Laurie Ryan, who provided oversight on behalf of the National Institute on Aging. The authors thank the members of the BIOCARD Resource Allocation Committee who provided ongoing guidance regarding the use of the biospecimens collected as part of the study, including Drs. Constantine Lyketsos, Carlos Pardo, Gerard Schellenberg, Leslie Shaw, Madhav Thambisetty, and John Trojanowski. The authors acknowledge the contributions of the Geriatric Psychiatry Branch of the intramural program of NIMH who initiated the study (Principal Investigator: Dr. Trey Sunderland). Funding Information: This study is supported by grants from the National Institutes of Health: 5U19-AG0336555 and R01NS084957. The BIOCARD Study consists of seven Cores with the following members: (1) the Administrative Core (MA and Rostislav Brichko); (2) the Clinical Core (MA, AS, CP, Rebecca Gottesman, Ned Sacktor, Scott Turner, Leonie Farrington, Maura Grega, Gay Rudow, Daniel D'Agostino, and Scott Rudow); (3) the Imaging Core (MM, Susumu Mori, Tilak Ratnanather, Timothy Brown, Hayan Chi, Anthony Kolasny, Kenichi Oishi, and Laurent Younes); (4) the Biospecimen Core (AM and Richard O'Brien); (5) the Informatics Core (Roberta Scherer, David Shade, Ann Ervin, Jennifer Jones, Hamadou Coulibaly, and April Patterson); (6) the Biostatistics Core (Mei-Cheng Wang, Daisy Zhu, and Jiangxia Wang); and (7) the Neuropathology Core (Juan Troncoso, Olga Pletnikova, Gay Rudow, and Karen Fisher). The authors are grateful to the members of the BIOCARD Scientific Advisory Board who provided continued oversight and guidance regarding the conduct of the study, including Drs. John Csernansky, David Holtzman, David Knopman, Walter Kukull, and Kevin Grimm, and Drs. John Hsiao and Laurie Ryan, who provided oversight on behalf of the National Institute on Aging. The authors thank the members of the BIOCARD Resource Allocation Committee who provided ongoing guidance regarding the use of the biospecimens collected as part of the study, including Drs. Constantine Lyketsos, Carlos Pardo, Gerard Schellenberg, Leslie Shaw, Madhav Thambisetty, and John Trojanowski. The authors acknowledge the contributions of the Geriatric Psychiatry Branch of the intramural program of NIMH who initiated the study (Principal Investigator: Dr. Trey Sunderland). Publisher Copyright: {\textcopyright} 2022 Elsevier B.V.",
year = "2022",
month = jun,
day = "11",
doi = "10.1016/j.neulet.2022.136618",
language = "English (US)",
volume = "781",
journal = "Neuroscience Letters",
issn = "0304-3940",
publisher = "Elsevier Ireland Ltd",
}