TY - JOUR
T1 - Changes in neuronal activation patterns in response to androgen deprivation therapy
T2 - A pilot study
AU - Cherrier, Monique M.
AU - Borghesani, Paul R.
AU - Shelton, Amy L.
AU - Higano, Celestia S.
N1 - Funding Information:
This study was supported in part by NIA K01AG00858, M01-RR-00037 and Department of Defense, Prostate Cancer Research Program (DAMD17-03-1-0045)-MMC and the Department of Veterans Affairs Puget Sound Health Care System (VHAPSHCS). PRB is supported by 1KL2RR025015-01 from the National Center for Research Resources (NCRR), a component of the National Institutes of Health (NIH) and NIH Roadmap for Medical Research. Views and opinions of, and endorsements by the author(s) do not reflect those of the USArmy or the Department of Defense. The authors wish to thank Marisa Johnson, Teresa Gambol, Jennifer Jenkins, and Jeff Stephenson for their excellent technical assistance.
PY - 2010/1/4
Y1 - 2010/1/4
N2 - Background: A common treatment option for men with prostate cancer is androgen deprivation therapy (ADT). However, men undergoing ADT may experience physical side effects, changes in quality of life and sometimes psychiatric and cognitive side effects.Methods: In this study, hormone naïve patients without evidence of metastases with a rising PSA were treated with nine months of ADT. Functional magnetic resonance imaging (fMRI) of the brain during three visuospatial tasks was performed at baseline prior to treatment and after nine months of ADT in five subjects. Seven healthy control patients, underwent neuroimaging at the same time intervals.Results: ADT patients showed reduced, task-related BOLD-fMRI activation during treatment that was not observed in control subjects. Reduction in activation in right parietal-occipital regions from baseline was observed during recall of the spatial location of objects and mental rotation.Conclusions: Findings, while preliminary, suggest that ADT reduces task-related neural activation in brain regions that are involved in mental rotation and accurate recall of spatial information.
AB - Background: A common treatment option for men with prostate cancer is androgen deprivation therapy (ADT). However, men undergoing ADT may experience physical side effects, changes in quality of life and sometimes psychiatric and cognitive side effects.Methods: In this study, hormone naïve patients without evidence of metastases with a rising PSA were treated with nine months of ADT. Functional magnetic resonance imaging (fMRI) of the brain during three visuospatial tasks was performed at baseline prior to treatment and after nine months of ADT in five subjects. Seven healthy control patients, underwent neuroimaging at the same time intervals.Results: ADT patients showed reduced, task-related BOLD-fMRI activation during treatment that was not observed in control subjects. Reduction in activation in right parietal-occipital regions from baseline was observed during recall of the spatial location of objects and mental rotation.Conclusions: Findings, while preliminary, suggest that ADT reduces task-related neural activation in brain regions that are involved in mental rotation and accurate recall of spatial information.
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U2 - 10.1186/1471-2407-10-1
DO - 10.1186/1471-2407-10-1
M3 - Article
C2 - 20047689
AN - SCOPUS:77349112001
SN - 1471-2407
VL - 10
JO - BMC cancer
JF - BMC cancer
M1 - 1
ER -