Changes in myocardial vasoreactivity after drastic reduction of plasma fibrinogen and cholesterol: A clinical study in long-term heart transplant survivors using positron emission tomography

Beate R. Jaeger, Frank M. Bengel, Kenichi Odaka, Peter Überfuhr, Carlos A. Labarrere, Stefan Bengsch, Clemens Engelschalk, Eckart Kreuzer, Bruno Reichart, Markus Schwaiger, Dietrich Seidel

Research output: Contribution to journalArticle

Abstract

Background: Given the central importance of the microvasculature in heart transplant recipients, we investigated the possibility of increasing cardiac perfusion after reduction of low-density lipoprotein (LDL)-cholesterol, lipoprotein (a), C-reactive protein (CRP) and fibrinogen plasma levels after apheresis treatment in transplanted patients. Methods: Ten long-term heart transplant recipients were examined with positron emission tomography (PET) to measure myocardial perfusion before and after a single heparin-mediated extracorporeal LDL/fibrinogen precipitation (HELP)-apheresis treatment. PET studies were performed the mornings before and after the apheresis treatment. Myocardial blood flow at rest and during adenosine-induced hyperemia was measured using 13N-ammonia. Results: HELP-apheresis reduced the plasma levels of LDL-cholesterol, lipoprotein (a) and C-reactive protein by 48% (p <0.001), fibrinogen by 42% (p = 0.02), plasma viscosity by 14% (p = 0.004) and erythrocyte aggregation by 28% (p <0.02). Osmolality (

Original languageEnglish (US)
Pages (from-to)2022-2030
Number of pages9
JournalJournal of Heart and Lung Transplantation
Volume24
Issue number12
DOIs
StatePublished - Dec 2005
Externally publishedYes

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Blood Component Removal
Positron-Emission Tomography
Fibrinogen
Survivors
Cholesterol
Transplants
Lipoprotein(a)
C-Reactive Protein
LDL Cholesterol
Heparin
Perfusion
Erythrocyte Aggregation
Hyperemia
Microvessels
LDL Lipoproteins
Ammonia
Viscosity
Adenosine
Osmolar Concentration
Therapeutics

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Surgery
  • Transplantation

Cite this

Changes in myocardial vasoreactivity after drastic reduction of plasma fibrinogen and cholesterol : A clinical study in long-term heart transplant survivors using positron emission tomography. / Jaeger, Beate R.; Bengel, Frank M.; Odaka, Kenichi; Überfuhr, Peter; Labarrere, Carlos A.; Bengsch, Stefan; Engelschalk, Clemens; Kreuzer, Eckart; Reichart, Bruno; Schwaiger, Markus; Seidel, Dietrich.

In: Journal of Heart and Lung Transplantation, Vol. 24, No. 12, 12.2005, p. 2022-2030.

Research output: Contribution to journalArticle

Jaeger, BR, Bengel, FM, Odaka, K, Überfuhr, P, Labarrere, CA, Bengsch, S, Engelschalk, C, Kreuzer, E, Reichart, B, Schwaiger, M & Seidel, D 2005, 'Changes in myocardial vasoreactivity after drastic reduction of plasma fibrinogen and cholesterol: A clinical study in long-term heart transplant survivors using positron emission tomography', Journal of Heart and Lung Transplantation, vol. 24, no. 12, pp. 2022-2030. https://doi.org/10.1016/j.healun.2005.05.009
Jaeger, Beate R. ; Bengel, Frank M. ; Odaka, Kenichi ; Überfuhr, Peter ; Labarrere, Carlos A. ; Bengsch, Stefan ; Engelschalk, Clemens ; Kreuzer, Eckart ; Reichart, Bruno ; Schwaiger, Markus ; Seidel, Dietrich. / Changes in myocardial vasoreactivity after drastic reduction of plasma fibrinogen and cholesterol : A clinical study in long-term heart transplant survivors using positron emission tomography. In: Journal of Heart and Lung Transplantation. 2005 ; Vol. 24, No. 12. pp. 2022-2030.
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T2 - A clinical study in long-term heart transplant survivors using positron emission tomography

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AU - Odaka, Kenichi

AU - Überfuhr, Peter

AU - Labarrere, Carlos A.

AU - Bengsch, Stefan

AU - Engelschalk, Clemens

AU - Kreuzer, Eckart

AU - Reichart, Bruno

AU - Schwaiger, Markus

AU - Seidel, Dietrich

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