TY - JOUR
T1 - Changes in kidney function among Nicaraguan sugarcane workers
AU - Laws, Rebecca L.
AU - Brooks, Daniel R.
AU - Amador, Juan José
AU - Weiner, Daniel E.
AU - Kaufman, James S.
AU - Ramírez-Rubio, Oriana
AU - Riefkohl, Alejandro
AU - Scammell, Madeleine K.
AU - López-Pilarte, Damaris
AU - Sánchez, José Marcel
AU - Parikh, Chirag R.
AU - McClean, Michael D.
N1 - Publisher Copyright:
© W. S. Maney & Son Ltd 2015.
PY - 2015/7/1
Y1 - 2015/7/1
N2 - Background: There is an epidemic of chronic kidney disease (CKD) of unknown etiology in Central American workers. Objectives: To investigate changes and job-specific differences in kidney function over a 6-month sugarcane harvest season, explore the potential role of hydration, and measure proteinuria. Methods: We recruited 284 Nicaraguan sugarcane workers performing seven distinct tasks. We measured urine albumin and serum creatinine and estimated glomerular filtration rate (eGFR). Results: eGFR varied by job and decreased during the harvest in seed cutters (-8.6 ml/min/1.73 m2), irrigators (-7.4 ml/min/1.73 m2), and cane cutters (-5.0 ml/min/1.73 m2), as compared to factory workers. The number of years employed at the company was negatively associated with eGFR. Fewer than 5% of workers had albumin-to-creatinine ratio (ACR)˃30 mg/g. Conclusions: The decline in kidney function during the harvest and the differences by job category and employment duration provide evidence that one or more risk factors of CKD are occupational.
AB - Background: There is an epidemic of chronic kidney disease (CKD) of unknown etiology in Central American workers. Objectives: To investigate changes and job-specific differences in kidney function over a 6-month sugarcane harvest season, explore the potential role of hydration, and measure proteinuria. Methods: We recruited 284 Nicaraguan sugarcane workers performing seven distinct tasks. We measured urine albumin and serum creatinine and estimated glomerular filtration rate (eGFR). Results: eGFR varied by job and decreased during the harvest in seed cutters (-8.6 ml/min/1.73 m2), irrigators (-7.4 ml/min/1.73 m2), and cane cutters (-5.0 ml/min/1.73 m2), as compared to factory workers. The number of years employed at the company was negatively associated with eGFR. Fewer than 5% of workers had albumin-to-creatinine ratio (ACR)˃30 mg/g. Conclusions: The decline in kidney function during the harvest and the differences by job category and employment duration provide evidence that one or more risk factors of CKD are occupational.
KW - Chronic kidney disease
KW - Chronic kidney disease of nontraditional etiology
KW - Estimated glomerular filtration rate
KW - Mesoamerican nephropathy
KW - Serum creatinine
KW - Tubulointerstitial
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U2 - 10.1179/2049396714Y.0000000102
DO - 10.1179/2049396714Y.0000000102
M3 - Article
C2 - 25631575
AN - SCOPUS:84932110192
SN - 1077-3525
VL - 21
SP - 241
EP - 250
JO - International Journal of Occupational and Environmental Health
JF - International Journal of Occupational and Environmental Health
IS - 3
ER -