Changes in kidney function among Nicaraguan sugarcane workers

Rebecca L. Laws, Daniel R. Brooks, Juan José Amador, Daniel E. Weiner, James S. Kaufman, Oriana Ramírez-Rubio, Alejandro Riefkohl, Madeleine K. Scammell, Damaris López-Pilarte, José Marcel Sánchez, Chirag Parikh, Michael D. McClean

Research output: Contribution to journalArticle

Abstract

Background: There is an epidemic of chronic kidney disease (CKD) of unknown etiology in Central American workers. Objectives: To investigate changes and job-specific differences in kidney function over a 6-month sugarcane harvest season, explore the potential role of hydration, and measure proteinuria. Methods: We recruited 284 Nicaraguan sugarcane workers performing seven distinct tasks. We measured urine albumin and serum creatinine and estimated glomerular filtration rate (eGFR). Results: eGFR varied by job and decreased during the harvest in seed cutters (-8.6 ml/min/1.73 m2), irrigators (-7.4 ml/min/1.73 m2), and cane cutters (-5.0 ml/min/1.73 m2), as compared to factory workers. The number of years employed at the company was negatively associated with eGFR. Fewer than 5% of workers had albumin-to-creatinine ratio (ACR)˃30 mg/g. Conclusions: The decline in kidney function during the harvest and the differences by job category and employment duration provide evidence that one or more risk factors of CKD are occupational.

Original languageEnglish (US)
Pages (from-to)241-250
Number of pages10
JournalInternational Journal of Occupational and Environmental Health
Volume21
Issue number3
DOIs
StatePublished - Jan 1 2015

Fingerprint

Saccharum
Glomerular Filtration Rate
Chronic Renal Insufficiency
Kidney
Creatinine
Canes
Proteinuria
Serum Albumin
Albumins
Seeds
Urine

Keywords

  • Chronic kidney disease
  • Chronic kidney disease of nontraditional etiology
  • Estimated glomerular filtration rate
  • Mesoamerican nephropathy
  • Serum creatinine
  • Tubulointerstitial

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health

Cite this

Laws, R. L., Brooks, D. R., Amador, J. J., Weiner, D. E., Kaufman, J. S., Ramírez-Rubio, O., ... McClean, M. D. (2015). Changes in kidney function among Nicaraguan sugarcane workers. International Journal of Occupational and Environmental Health, 21(3), 241-250. https://doi.org/10.1179/2049396714Y.0000000102

Changes in kidney function among Nicaraguan sugarcane workers. / Laws, Rebecca L.; Brooks, Daniel R.; Amador, Juan José; Weiner, Daniel E.; Kaufman, James S.; Ramírez-Rubio, Oriana; Riefkohl, Alejandro; Scammell, Madeleine K.; López-Pilarte, Damaris; Sánchez, José Marcel; Parikh, Chirag; McClean, Michael D.

In: International Journal of Occupational and Environmental Health, Vol. 21, No. 3, 01.01.2015, p. 241-250.

Research output: Contribution to journalArticle

Laws, RL, Brooks, DR, Amador, JJ, Weiner, DE, Kaufman, JS, Ramírez-Rubio, O, Riefkohl, A, Scammell, MK, López-Pilarte, D, Sánchez, JM, Parikh, C & McClean, MD 2015, 'Changes in kidney function among Nicaraguan sugarcane workers', International Journal of Occupational and Environmental Health, vol. 21, no. 3, pp. 241-250. https://doi.org/10.1179/2049396714Y.0000000102
Laws, Rebecca L. ; Brooks, Daniel R. ; Amador, Juan José ; Weiner, Daniel E. ; Kaufman, James S. ; Ramírez-Rubio, Oriana ; Riefkohl, Alejandro ; Scammell, Madeleine K. ; López-Pilarte, Damaris ; Sánchez, José Marcel ; Parikh, Chirag ; McClean, Michael D. / Changes in kidney function among Nicaraguan sugarcane workers. In: International Journal of Occupational and Environmental Health. 2015 ; Vol. 21, No. 3. pp. 241-250.
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