Changes in intrinsic functional brain networks following blast-induced mild traumatic brain injury

Andrei A. Vakhtin, Vince D. Calhoun, Rex E. Jung, Jillian L. Prestopnik, Paul A. Taylor, Corey C. Ford

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: Blast-induced mild traumatic brain injuries (mTBI) commonly go undetected by computed tomography and conventional magnetic resonance imaging (MRI). This study was used to investigate functional brain network abnormalities in a group of blast-induced mTBI subjects using independent component analysis (ICA) of resting state functional MRI (fMRI) data. Methods: Twenty-eight resting state networks of 13 veterans who sustained blast-induced mTBI were compared with healthy controls across three fMRI domains: blood oxygenation level-dependent spatial maps, time course spectra and functional connectivity. Results: The mTBI group exhibited hyperactivity in the temporo-parietal junctions and hypoactivity in the left inferior temporal gyrus. Abnormal frequencies in default-mode (DMN), sensorimotor, attentional and frontal networks were detected. In addition, functional connectivity was disrupted in six network pairs: DMN-basal ganglia, attention-sensorimotor, frontal-DMN, attention-sensorimotor, attention-frontal and sensorimotor-sensorimotor. Conclusions: The results suggest white matter disruption across certain attentional networks. Additionally, given their elevated activity relative to controls', the temporo-parietal junctions of blast mTBI subjects may be compensating for diffuse axonal injury in other cortical regions.

Original languageEnglish (US)
Pages (from-to)1304-1310
Number of pages7
JournalBrain Injury
Volume27
Issue number11
DOIs
StatePublished - 2013

Keywords

  • Blast
  • Cognition
  • Functional magnetic resonance imaging (fMRI)
  • Independent component analysis (ICA)
  • Mild traumatic brain injury (mTBI)
  • Resting state networks (RSN)

ASJC Scopus subject areas

  • Neuroscience (miscellaneous)
  • Developmental and Educational Psychology
  • Clinical Neurology

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