Changes in host defence induced by malignancies and antineoplastic treatment: implication for immunotherapeutic strategies

Thomas Lehrnbecher, Ulrike Koehl, Boris Wittekindt, Konrad Bochennek, Lars Tramsen, Thomas Klingebiel, Stephen J. Chanock

Research output: Contribution to journalReview article

Abstract

Changes of the immune system can be a consequence of an underlying malignancy or induced by antineoplastic treatment. Both influence the risk for infectious complications and relapse. Over the past decade, there have been a series of major developments in the laboratory assessment of immune dysfunction, particularly as it relates to the complex interactions of the distinct components of the immune system. In addition, several new therapeutic strategies that modulate the immune system have been introduced. We review new findings that can affect clinical decision making. Better insights into the impairment of host response could provide the rationale for the development of new therapeutic strategies, for both supportive care and anticancer treatment.

Original languageEnglish (US)
Pages (from-to)269-278
Number of pages10
JournalThe Lancet Oncology
Volume9
Issue number3
DOIs
StatePublished - Mar 1 2008

ASJC Scopus subject areas

  • Oncology

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    Lehrnbecher, T., Koehl, U., Wittekindt, B., Bochennek, K., Tramsen, L., Klingebiel, T., & Chanock, S. J. (2008). Changes in host defence induced by malignancies and antineoplastic treatment: implication for immunotherapeutic strategies. The Lancet Oncology, 9(3), 269-278. https://doi.org/10.1016/S1470-2045(08)70071-8