Changes in Erythrocyte Enzyme Activities during Erythrocyte Aging in Alcoholism

Esteban Mezey, Deborah L. Rhodes

Research output: Contribution to journalArticlepeer-review

Abstract

Aldehyde dehydrogenase, glucose‐6‐phosphate dehydrogenase, and pyruvate kinase activities were determined in erythrocytes of various ages, separated by Percoll gradient centrifugation, in 13 alcoholic patients and eight control subjects. The total erythrocyte activities of all three enzymes were not affected by alcoholism, however, the youngest cells of alcoholics had a decreased aldehyde dehydrogenase activity, while both glucose‐6‐phosphate dehydrogenase and pyruvate kinase activities were increased. The depression of aldehyde dehydrogenase activity not only persisted, but became more marked after 2 weeks of abstinence, while the enhanced activities of the two other enzymes returned to normal. These observations suggest that chronic alcohol ingestion suppresses aldehyde dehydrogenase in the bone marrow, while it enhances other erythrocytic enzymes.

Original languageEnglish (US)
Pages (from-to)422-426
Number of pages5
JournalAlcoholism: Clinical and Experimental Research
Volume12
Issue number3
DOIs
StatePublished - Jun 1988

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Toxicology
  • Psychiatry and Mental health

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