Changes in Epstein-Barr virus antibody titers associated with aging

R. Glaser, Eric C Strain, K. L. Tarr, J. E. Holliday, R. L. Donnerberg, J. K. Kiecolt-Glaser

Research output: Contribution to journalArticle

Abstract

Antibody titers to the Epstein-Barr virus (EBV), early antigen (EA) IgG, and virus capsid antigen (VCA) IgG and IgA, were measured in 44 geriatric subjects to determine if the depression in cellular immunity known to be associated with aging affects the expression of latent EBV. Similar assays were performed on plasma obtained from a young adult (medical student) population as a control group. We found that 89% of geriatric samples were positive for EA IgG, and 83% of the plasma obtained from medical students were positive for EA IgG. One hundred percent of the geriatric subjects were positive for VCA IgG, and 87% of the medical students were positive for VCA IgG. Seven percent of the medical student blood samples were positive for VCA IgA; in contrast, 36% of the blood samples obtained from the geriatrics subjects were positive. Significant differences were also found in the geometric mean titers (GMT) of antibodies to EBV antigens; the GMT to EBV EA and VCA were significantly higher in the geriatric group. The data suggest that there may be some loss of control over latent EBV by the cellular immune response in geriatric individuals.

Original languageEnglish (US)
Pages (from-to)352-355
Number of pages4
JournalExperimental Biology and Medicine
Volume179
Issue number3
StatePublished - 1985
Externally publishedYes

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Geriatrics
Viral Load
Human Herpesvirus 4
Viruses
Aging of materials
Capsid
Antigens
Antibodies
Immunoglobulin G
Medical Students
Students
Cellular Immunity
Immunoglobulin A
Blood
Plasmas
Young Adult
Assays
Control Groups
Population

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Glaser, R., Strain, E. C., Tarr, K. L., Holliday, J. E., Donnerberg, R. L., & Kiecolt-Glaser, J. K. (1985). Changes in Epstein-Barr virus antibody titers associated with aging. Experimental Biology and Medicine, 179(3), 352-355.

Changes in Epstein-Barr virus antibody titers associated with aging. / Glaser, R.; Strain, Eric C; Tarr, K. L.; Holliday, J. E.; Donnerberg, R. L.; Kiecolt-Glaser, J. K.

In: Experimental Biology and Medicine, Vol. 179, No. 3, 1985, p. 352-355.

Research output: Contribution to journalArticle

Glaser, R, Strain, EC, Tarr, KL, Holliday, JE, Donnerberg, RL & Kiecolt-Glaser, JK 1985, 'Changes in Epstein-Barr virus antibody titers associated with aging', Experimental Biology and Medicine, vol. 179, no. 3, pp. 352-355.
Glaser R, Strain EC, Tarr KL, Holliday JE, Donnerberg RL, Kiecolt-Glaser JK. Changes in Epstein-Barr virus antibody titers associated with aging. Experimental Biology and Medicine. 1985;179(3):352-355.
Glaser, R. ; Strain, Eric C ; Tarr, K. L. ; Holliday, J. E. ; Donnerberg, R. L. ; Kiecolt-Glaser, J. K. / Changes in Epstein-Barr virus antibody titers associated with aging. In: Experimental Biology and Medicine. 1985 ; Vol. 179, No. 3. pp. 352-355.
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