Changes in causes of death after renal transplantation, 1966 to 1987

Martha Hill, R. A. Grossman, H. I. Feldman, S. Hurwitz, D. C. Dafoe

Research output: Contribution to journalArticle

Abstract

This descriptive study was undertaken to examine survival and changes in cause of death after renal transplantation. One fourth (259) of the 1,022 patients who received a renal transplant between 1966 and 1987 at the University of Pennsylvania had died by January 1, 1988. Causes of death for 246 (96%) of the deceased patients were analyzed. Despite an increase in age and number of comorbid diseases before transplantation, posttransplant survival increased significantly over the study period. All-cause mortality rates at 1, 2, and 5 years decreased significantly. Infectious disease cumulative mortality rates at 1, 2, and 5 years also decreased between 1966 and 1985. No trend in the 1-, 2-, or 5-year cardiovascular disease cumulative mortality rates was detected. The decline in the rate of deaths due to infection led to a decrease in the proportion of infection-related deaths and an associated increase in the proportion of cardiovascular disease-related deaths. The reduction in mortality over the past 2 decades is associated with the simultaneous improvement in immunosuppression and treatment of infectious diseases.

Original languageEnglish (US)
Pages (from-to)512-518
Number of pages7
JournalAmerican Journal of Kidney Diseases
Volume17
Issue number5
StatePublished - 1991
Externally publishedYes

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Kidney Transplantation
Cause of Death
Mortality
Communicable Diseases
Cardiovascular Diseases
Survival
Infection
Immunosuppression
Transplantation
Transplants
Kidney
Therapeutics

ASJC Scopus subject areas

  • Nephrology

Cite this

Hill, M., Grossman, R. A., Feldman, H. I., Hurwitz, S., & Dafoe, D. C. (1991). Changes in causes of death after renal transplantation, 1966 to 1987. American Journal of Kidney Diseases, 17(5), 512-518.

Changes in causes of death after renal transplantation, 1966 to 1987. / Hill, Martha; Grossman, R. A.; Feldman, H. I.; Hurwitz, S.; Dafoe, D. C.

In: American Journal of Kidney Diseases, Vol. 17, No. 5, 1991, p. 512-518.

Research output: Contribution to journalArticle

Hill, M, Grossman, RA, Feldman, HI, Hurwitz, S & Dafoe, DC 1991, 'Changes in causes of death after renal transplantation, 1966 to 1987', American Journal of Kidney Diseases, vol. 17, no. 5, pp. 512-518.
Hill, Martha ; Grossman, R. A. ; Feldman, H. I. ; Hurwitz, S. ; Dafoe, D. C. / Changes in causes of death after renal transplantation, 1966 to 1987. In: American Journal of Kidney Diseases. 1991 ; Vol. 17, No. 5. pp. 512-518.
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