Changes in cardiac excitability and vulnerability in NMR fields

John U. Doherty, Glenn J.R. Whitman, Murray D. Robinson, Alden H. Harken, Michael B. Simson, Joseph F. Spear, Mark E. Josephson

Research output: Contribution to journalArticlepeer-review

Abstract

Alterations in ventricular excitability and vulnerability were assessed in nine isolated perfused rabbit hearts in and out of static external magnetic fields (4.7 tesla) associated with radiofrequency pulsing (5 gauss). Ventricular refractoriness was assessed with the strength interval relationship in and out of the NMR magnet. Strength interval curves were measured at threshold, at the midpoint of the strength interval relationship, and at 10 mA. The refractory period measured at threshold was 193 ± 24 mS outside the magnet and 195 ± 24 mS inside the magnet (P=ns). Ventricular refractoriness measured at the midpoint of the strength interval curve was 169 ± 16 mS outside and 167 ± 17 mS in the magnet (P = ns). At 10 mA the refractory period outside of the magnet was 162 ± 16 mS and 161 ± 17 mS in the magnet (P = ns).

Original languageEnglish (US)
Pages (from-to)129-135
Number of pages7
JournalInvestigative radiology
Volume20
Issue number2
DOIs
StatePublished - 1985

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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