Changes in arterial oxygenation and self-reported oxygen use after lung volume reduction surgery

Margaret L. Snyder, Christopher H. Goss, Blazej Neradilek, Nayak L. Polissar, Zab Mosenifar, Robert A. Wise, Alfred P. Fishman, Joshua O. Benditt

Research output: Contribution to journalArticlepeer-review


Rationale: Lung volume reduction surgery (LVRS) is inconsistently reported to improve arterial oxygenation in patients with chronic obstructive pulmonary disease. Objectives: We studied the effects of surgery on oxygenation in a large cohort and identified predictors of postoperative oxygenation improvement. Methods: We evaluated oxygenation in 1,078 subjects with chronic obstructive pulmonary disease enrolled in the National Emphysema Treatment Trial after LVRS compared with medical control subjects, including arterial blood gases, use of supplemental oxygen during treadmill walking, and self-reported use of oxygen during rest, exertion, and sleep. Measurements and Main Results: PaO2 breathing room air was equal in medical and surgical subjects at baseline (64.8 vs. 65.0 mm Hg, P = not significant), but lower in medical subjects at 6 months (63.6 vs. 70.0 mm Hg, P < 0.001), 12 months (63.9 vs. 68.7 mm Hg, P < 0.001), and 24 months (62.4 vs. 68.0 mm Hg, P < 0.001). Fewer medical subjects required oxygen for treadmill walking at baseline compared with surgical subjects (46 vs. 53%, P = 0.02). However, more medical subjects requiredoxygenfor this activity at 6 months (49 vs.33%, P < 0.001), 12 months (50 vs. 36%, P < 0.001), and 24 months (52 vs. 42%, P = 0.02). Self-reported oxygen use was greater in medical than in surgical subjects at 6, 12, and 24 months. Multivariate modeling of preoperative characteristics showed baseline oxygenation status was the best predictor of postoperative oxygenation. Conclusions: LVRS increases PaO2, and decreases treadmill and self-reported use of oxygen for up to 24 months post-procedure. Clinical trial registered with (NCT 00000606).

Original languageEnglish (US)
Pages (from-to)339-345
Number of pages7
JournalAmerican journal of respiratory and critical care medicine
Issue number4
StatePublished - Aug 15 2008


  • Emphysema
  • Lung diseases, obstructive
  • Oxygen inhalation therapy

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine


Dive into the research topics of 'Changes in arterial oxygenation and self-reported oxygen use after lung volume reduction surgery'. Together they form a unique fingerprint.

Cite this