Changes in anterior segment dimensions over 4 years in a cohort of Singaporean subjects with open angles

Yingke He, Mani Baskaran, Arun K. Narayanaswamy, Lisandro M. Sakata, Renyi Wu, Dianna Liu, Monisha E. Nongpiur, Mingguang He, David S Friedman, Tin Aung

Research output: Contribution to journalArticle

Abstract

Aim To evaluate quantitative changes in anterior segment optical coherence tomography (AS-OCT) parameters at 4 years in subjects with open angles on gonioscopy at baseline. Methods 339 gonioscopically open-angle subjects aged >50 years underwent AS-OCT imaging (Visante, Carl Zeiss Meditec, Dublin, California, USA) at baseline and at 4 years. Customised software was used to analyse images. Linear regression was performed to assess baseline predictors of change in mean trabecular iris space area (TISA). Results Of the 339 subjects, 204 (61%) had good images for analysis. The mean age at baseline was 60 (SD 6.42) years; 55.4% were women and 87.7% were Chinese. Overall, there was a decrease in anterior chamber depth (ACD), anterior chamber area (ACA), anterior chamber volume (ACV) and angle opening distance at 500/750 mm, TISA 500/750 mm, iris thickness at 2000 mm and iris area in both nasal and temporal quadrants ( p

Original languageEnglish (US)
Pages (from-to)1097-1102
Number of pages6
JournalBritish Journal of Ophthalmology
Volume99
Issue number8
DOIs
StatePublished - Aug 1 2015

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Iris
Anterior Chamber
Optical Coherence Tomography
Gonioscopy
Nose
Linear Models
Software

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience
  • Medicine(all)

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Changes in anterior segment dimensions over 4 years in a cohort of Singaporean subjects with open angles. / He, Yingke; Baskaran, Mani; Narayanaswamy, Arun K.; Sakata, Lisandro M.; Wu, Renyi; Liu, Dianna; Nongpiur, Monisha E.; He, Mingguang; Friedman, David S; Aung, Tin.

In: British Journal of Ophthalmology, Vol. 99, No. 8, 01.08.2015, p. 1097-1102.

Research output: Contribution to journalArticle

He, Y, Baskaran, M, Narayanaswamy, AK, Sakata, LM, Wu, R, Liu, D, Nongpiur, ME, He, M, Friedman, DS & Aung, T 2015, 'Changes in anterior segment dimensions over 4 years in a cohort of Singaporean subjects with open angles', British Journal of Ophthalmology, vol. 99, no. 8, pp. 1097-1102. https://doi.org/10.1136/bjophthalmol-2014-305816
He, Yingke ; Baskaran, Mani ; Narayanaswamy, Arun K. ; Sakata, Lisandro M. ; Wu, Renyi ; Liu, Dianna ; Nongpiur, Monisha E. ; He, Mingguang ; Friedman, David S ; Aung, Tin. / Changes in anterior segment dimensions over 4 years in a cohort of Singaporean subjects with open angles. In: British Journal of Ophthalmology. 2015 ; Vol. 99, No. 8. pp. 1097-1102.
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