Changes in anterior segment dimensions over 4 years in a cohort of Singaporean subjects with open angles

Yingke He, Mani Baskaran, Arun K. Narayanaswamy, Lisandro M. Sakata, Renyi Wu, Dianna Liu, Monisha E. Nongpiur, Mingguang He, David S. Friedman, Tin Aung

Research output: Contribution to journalArticlepeer-review


Aim To evaluate quantitative changes in anterior segment optical coherence tomography (AS-OCT) parameters at 4 years in subjects with open angles on gonioscopy at baseline. Methods 339 gonioscopically open-angle subjects aged >50 years underwent AS-OCT imaging (Visante, Carl Zeiss Meditec, Dublin, California, USA) at baseline and at 4 years. Customised software was used to analyse images. Linear regression was performed to assess baseline predictors of change in mean trabecular iris space area (TISA). Results Of the 339 subjects, 204 (61%) had good images for analysis. The mean age at baseline was 60 (SD 6.42) years; 55.4% were women and 87.7% were Chinese. Overall, there was a decrease in anterior chamber depth (ACD), anterior chamber area (ACA), anterior chamber volume (ACV) and angle opening distance at 500/750 mm, TISA 500/750 mm, iris thickness at 2000 mm and iris area in both nasal and temporal quadrants ( p<0.05) at 4 years. There was an increase in iris curvature (ICURV) and lens vault (LV) ( p<0.05). With univariate analysis, shorter axial length (AxL), shallower ACD, greater LV, smaller ACA/ACV and larger mean ICURV at baseline were associated with less change in TISA750 at follow-up. On multivariate analysis, only baseline mean ICURV and shorter AxL were predictive of less change in TISA750 at 4 years. Conclusions Angle width significantly decreased; ICURV and LV increased in subjects with gonioscopically open angles followed at 4 years. Eyes with shorter AxL and greater ICURV at baseline had lesser decrease in angle width.

Original languageEnglish (US)
Pages (from-to)1097-1102
Number of pages6
JournalBritish Journal of Ophthalmology
Issue number8
StatePublished - Aug 1 2015

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience


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