Changepoint analysis of putamen and thalamus subregions in premanifest huntington's disease

Xiaoqing Tan, Christopher A. Ross, Michaeli Miller, Xiaoying Tang

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Huntington's disease (HD) is a progressive inherited brain disorder that affects cognition, personality and physical abilities. Advanced statistical shape analysis pipelines have shown that region-specific shape abnormalities of the putamen and thalamus begin earlier than clinical onset ('premanifest' period), but the order and pattern of different subregions' abnormalities of those two structures are still unclear. In this paper, we applied a multivariate linear mixed-effects model, in combination with a novel shape diffeomorphometry technique, to identify the changepoints at which the shape morphometry abnormalities of different putamen and thalamus sub-regions start. Our experimental results revealed that the putamen was affected severely by HD whereas the thalamus was affected in a milder way. The putaminal subregion connected to the executive cortex and the thalamic subregion connected to the prefrontal cortex were found to be affected the earliest by HD. This study contributes to a better understanding of the temporal ordering of the putaminal and thalamic abnormalities of different functionally-distinct subregions.

Original languageEnglish (US)
Title of host publication2018 IEEE 15th International Symposium on Biomedical Imaging, ISBI 2018
PublisherIEEE Computer Society
Pages531-535
Number of pages5
ISBN (Electronic)9781538636367
DOIs
StatePublished - May 23 2018
Event15th IEEE International Symposium on Biomedical Imaging, ISBI 2018 - Washington, United States
Duration: Apr 4 2018Apr 7 2018

Publication series

NameProceedings - International Symposium on Biomedical Imaging
Volume2018-April
ISSN (Print)1945-7928
ISSN (Electronic)1945-8452

Other

Other15th IEEE International Symposium on Biomedical Imaging, ISBI 2018
CountryUnited States
CityWashington
Period4/4/184/7/18

Keywords

  • Changepoint onset model
  • Premanifest Huntington's disease
  • Putamen
  • Subregional shape analysis
  • Thalamus

ASJC Scopus subject areas

  • Biomedical Engineering
  • Radiology Nuclear Medicine and imaging

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