@inproceedings{93c45ac5511f43ecb69ba734c49a9f32,
title = "Change point estimation of the hippocampal volumes in Alzheimer's disease",
abstract = "Volumetric changes in the hippocampus have been shown to precede clinical symptom onset during the preclinical phase of Alzheimer's disease (AD). In this paper, we propose a novel statistical method for estimating the change point of the hippocampus, as extracted from structural magnetic resonance imaging scans, in relation to clinical symptom onset. We used a linear mixed-effect statistical model. Maximum likelihood estimation was employed as the strategy that was applied in two phases.",
keywords = "Alzheimer's disease, Change point, Hippocampus, Linear mixed-effects, Maximum likelihood estimation",
author = "Xiaoying Tang and Marilyn Albert and Miller, {Michael I.} and Laurent Younes",
note = "Funding Information: This work was partially supported by the National Natural Science Foundation of China (81501546), the SYSU-CMU Shunde International Joint Research Institute Start-up Grant (20150306), the National Institutes of Health (U19-AG03365, P50-AG005146, R01-EB017638, R01-NS084957, and P41-EB015909), the Office of Naval Research (ONR-90048203), and the National Science Foundation (ACI-1053575) for the Computational Anatomy Gateway via Extreme Science and Engineering Discovery Environment (XSEDE) and the Kavli founation via the Kavli Neuroscience Discovery Institute. We thank the entire BIOCARD study team for their continuing contributions to this work. We would also like to thank Jiong Wu from the SYSU-CMU Joint Institute of Engineering for his help in editing this manuscript. Publisher Copyright: {\textcopyright} 2016 IEEE.; 13th Conference on Computer and Robot Vision, CRV 2016 ; Conference date: 01-06-2016 Through 03-06-2016",
year = "2016",
month = dec,
day = "28",
doi = "10.1109/CRV.2016.13",
language = "English (US)",
series = "Proceedings - 2016 13th Conference on Computer and Robot Vision, CRV 2016",
publisher = "Institute of Electrical and Electronics Engineers Inc.",
pages = "358--361",
editor = "Juan Guerrero",
booktitle = "Proceedings - 2016 13th Conference on Computer and Robot Vision, CRV 2016",
}