Abstract
Melanoma cells can switch from a highly proliferative, less invasive state to a highly invasive, less proliferative state, a phenomenon termed phenotype switching. This results in a highly heterogenous tumor, where a slow-growing, aggressive population of cells may resist tumor therapy, and it predicts tumor recurrence. Here we discuss the observation made by Widmer et al. that hypoxia may drive phenotype switching.
Original language | English (US) |
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Pages (from-to) | 2316-2317 |
Number of pages | 2 |
Journal | Journal of Investigative Dermatology |
Volume | 133 |
Issue number | 10 |
DOIs |
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State | Published - Oct 2013 |
Externally published | Yes |
ASJC Scopus subject areas
- Biochemistry
- Molecular Biology
- Dermatology
- Cell Biology