Change is in the air: The hypoxic induction of phenotype switching in melanoma

Michael P. O'Connell; Ashani T. Weeraratna

doi:10.1038/jid.2013.208

Change is in the air: The hypoxic induction of phenotype switching in melanoma

Michael P. O'Connell, Ashani T. Weeraratna

Research output: Contribution to journal › Comment/debate › peer-review

Abstract

Melanoma cells can switch from a highly proliferative, less invasive state to a highly invasive, less proliferative state, a phenomenon termed phenotype switching. This results in a highly heterogenous tumor, where a slow-growing, aggressive population of cells may resist tumor therapy, and it predicts tumor recurrence. Here we discuss the observation made by Widmer et al. that hypoxia may drive phenotype switching.

Original language	English (US)
Pages (from-to)	2316-2317
Number of pages	2
Journal	Journal of Investigative Dermatology
Volume	133
Issue number	10
DOIs	https://doi.org/10.1038/jid.2013.208
State	Published - Oct 2013
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Dermatology
Cell Biology

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title = "Change is in the air: The hypoxic induction of phenotype switching in melanoma",

abstract = "Melanoma cells can switch from a highly proliferative, less invasive state to a highly invasive, less proliferative state, a phenomenon termed phenotype switching. This results in a highly heterogenous tumor, where a slow-growing, aggressive population of cells may resist tumor therapy, and it predicts tumor recurrence. Here we discuss the observation made by Widmer et al. that hypoxia may drive phenotype switching.",

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AB - Melanoma cells can switch from a highly proliferative, less invasive state to a highly invasive, less proliferative state, a phenomenon termed phenotype switching. This results in a highly heterogenous tumor, where a slow-growing, aggressive population of cells may resist tumor therapy, and it predicts tumor recurrence. Here we discuss the observation made by Widmer et al. that hypoxia may drive phenotype switching.

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Change is in the air: The hypoxic induction of phenotype switching in melanoma

Abstract

ASJC Scopus subject areas

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