Change is in the air: The hypoxic induction of phenotype switching in melanoma

Michael P. O'Connell, Ashani T. Weeraratna

Research output: Contribution to journalComment/debatepeer-review

Abstract

Melanoma cells can switch from a highly proliferative, less invasive state to a highly invasive, less proliferative state, a phenomenon termed phenotype switching. This results in a highly heterogenous tumor, where a slow-growing, aggressive population of cells may resist tumor therapy, and it predicts tumor recurrence. Here we discuss the observation made by Widmer et al. that hypoxia may drive phenotype switching.

Original languageEnglish (US)
Pages (from-to)2316-2317
Number of pages2
JournalJournal of Investigative Dermatology
Volume133
Issue number10
DOIs
StatePublished - Oct 2013
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Dermatology
  • Cell Biology

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