Change in muscle strength explains accelerated decline of physical function in older women with high interleukin-6 serum levels

Luigi Ferrucci, Brenda W J H Penninx, Stefano Volpato, Tamara B. Harris, Karen J Bandeen Roche, Jennifer Balfour, Suzanne G. Leveille, Linda P Fried, Jack M. Guralnik

Research output: Contribution to journalArticle

Abstract

OBJECTIVES: To test whether accelerated sarcopenia in older persons with high interleukin (IL)-6 serum levels plays a role in the prospective association between inflammation and disability found in many studies. DESIGN: Cohort study of older women with moderate to severe disability. PARTICIPANTS: Six hundred twenty older women from the Women's Health and Aging Study in whom information on baseline IL-6 serum level was available. MEASUREMENTS: Self-report of functional status, objective measures of walking performance, and knee extensor strength were assessed at baseline and over six semiannual follow-up visits. Potential confounders were baseline age, race, body mass index, smoking, depression, and medical conditions. RESULTS: At baseline, women with high IL-6 were more often disabled and had lower walking speed. After adjusting for confounders, women in the highest IL-6 tertile (IL-6 >3.10 pg/mL) were at higher risk of developing incident mobility disability (risk ratio (RR) = 1.50, 95% confidence interval (CI) = 1.01-2.27), disability in activities of daily living (RR = 1.41, 95% CI = 1.01-1.98), and severe limitation in walking (RR = 1.61, 95% CI = 1.09-2.38) and experienced steeper declines in walking speed (P <.001) than women in the lowest IL-6 tertile (IL-6 ≤1.78 pg/mL). Decline in knee extensor strength was also steeper, but differences across IL-6 tertiles were not significant. After adjusting for change over time in knee extensor strength, the association between high IL-6 and accelerated decline of physical function was no longer statistically significant. CONCLUSIONS: Older women with high IL-6 serum levels have a higher risk of developing physical disability and experience a steeper decline in walking ability than those with lower levels, which are partially explained by a parallel decline in muscle strength.

Original languageEnglish (US)
Pages (from-to)1947-1954
Number of pages8
JournalJournal of the American Geriatrics Society
Volume50
Issue number12
DOIs
StatePublished - Dec 1 2002

Fingerprint

Muscle Strength
Interleukin-6
Serum
Walking
Knee
Odds Ratio
Confidence Intervals
Sarcopenia
Aptitude
Women's Health
Activities of Daily Living
Self Report
Body Mass Index
Cohort Studies
Smoking
Depression
Inflammation

Keywords

  • Aging
  • Cytokines
  • Disability
  • IL-6
  • Inflammation
  • Older women

ASJC Scopus subject areas

  • Geriatrics and Gerontology

Cite this

Change in muscle strength explains accelerated decline of physical function in older women with high interleukin-6 serum levels. / Ferrucci, Luigi; Penninx, Brenda W J H; Volpato, Stefano; Harris, Tamara B.; Bandeen Roche, Karen J; Balfour, Jennifer; Leveille, Suzanne G.; Fried, Linda P; Guralnik, Jack M.

In: Journal of the American Geriatrics Society, Vol. 50, No. 12, 01.12.2002, p. 1947-1954.

Research output: Contribution to journalArticle

Ferrucci, Luigi ; Penninx, Brenda W J H ; Volpato, Stefano ; Harris, Tamara B. ; Bandeen Roche, Karen J ; Balfour, Jennifer ; Leveille, Suzanne G. ; Fried, Linda P ; Guralnik, Jack M. / Change in muscle strength explains accelerated decline of physical function in older women with high interleukin-6 serum levels. In: Journal of the American Geriatrics Society. 2002 ; Vol. 50, No. 12. pp. 1947-1954.
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abstract = "OBJECTIVES: To test whether accelerated sarcopenia in older persons with high interleukin (IL)-6 serum levels plays a role in the prospective association between inflammation and disability found in many studies. DESIGN: Cohort study of older women with moderate to severe disability. PARTICIPANTS: Six hundred twenty older women from the Women's Health and Aging Study in whom information on baseline IL-6 serum level was available. MEASUREMENTS: Self-report of functional status, objective measures of walking performance, and knee extensor strength were assessed at baseline and over six semiannual follow-up visits. Potential confounders were baseline age, race, body mass index, smoking, depression, and medical conditions. RESULTS: At baseline, women with high IL-6 were more often disabled and had lower walking speed. After adjusting for confounders, women in the highest IL-6 tertile (IL-6 >3.10 pg/mL) were at higher risk of developing incident mobility disability (risk ratio (RR) = 1.50, 95{\%} confidence interval (CI) = 1.01-2.27), disability in activities of daily living (RR = 1.41, 95{\%} CI = 1.01-1.98), and severe limitation in walking (RR = 1.61, 95{\%} CI = 1.09-2.38) and experienced steeper declines in walking speed (P <.001) than women in the lowest IL-6 tertile (IL-6 ≤1.78 pg/mL). Decline in knee extensor strength was also steeper, but differences across IL-6 tertiles were not significant. After adjusting for change over time in knee extensor strength, the association between high IL-6 and accelerated decline of physical function was no longer statistically significant. CONCLUSIONS: Older women with high IL-6 serum levels have a higher risk of developing physical disability and experience a steeper decline in walking ability than those with lower levels, which are partially explained by a parallel decline in muscle strength.",
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AU - Bandeen Roche, Karen J

AU - Balfour, Jennifer

AU - Leveille, Suzanne G.

AU - Fried, Linda P

AU - Guralnik, Jack M.

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AB - OBJECTIVES: To test whether accelerated sarcopenia in older persons with high interleukin (IL)-6 serum levels plays a role in the prospective association between inflammation and disability found in many studies. DESIGN: Cohort study of older women with moderate to severe disability. PARTICIPANTS: Six hundred twenty older women from the Women's Health and Aging Study in whom information on baseline IL-6 serum level was available. MEASUREMENTS: Self-report of functional status, objective measures of walking performance, and knee extensor strength were assessed at baseline and over six semiannual follow-up visits. Potential confounders were baseline age, race, body mass index, smoking, depression, and medical conditions. RESULTS: At baseline, women with high IL-6 were more often disabled and had lower walking speed. After adjusting for confounders, women in the highest IL-6 tertile (IL-6 >3.10 pg/mL) were at higher risk of developing incident mobility disability (risk ratio (RR) = 1.50, 95% confidence interval (CI) = 1.01-2.27), disability in activities of daily living (RR = 1.41, 95% CI = 1.01-1.98), and severe limitation in walking (RR = 1.61, 95% CI = 1.09-2.38) and experienced steeper declines in walking speed (P <.001) than women in the lowest IL-6 tertile (IL-6 ≤1.78 pg/mL). Decline in knee extensor strength was also steeper, but differences across IL-6 tertiles were not significant. After adjusting for change over time in knee extensor strength, the association between high IL-6 and accelerated decline of physical function was no longer statistically significant. CONCLUSIONS: Older women with high IL-6 serum levels have a higher risk of developing physical disability and experience a steeper decline in walking ability than those with lower levels, which are partially explained by a parallel decline in muscle strength.

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