Abstract
Micro-Abstract Immunoglobulin heavy chain mutational status of chronic lymphocytic leukemia is used to predict outcome, and is considered stable over time. We examined mutational status in a 56 patients cohort study, and identified 7 who changed mutational status. This supports the multiclonal nature of chronic lymphocytic leukemia and suggests a cell of origin that has not yet rearranged or is capable of continuing to rearrange and mutate its immunoglobulin genes.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 97-99 |
| Number of pages | 3 |
| Journal | Clinical Lymphoma, Myeloma and Leukemia |
| Volume | 17 |
| Issue number | 2 |
| DOIs | |
| State | Published - Feb 1 2017 |
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Keywords
- Cancer stem cell
- CLL
- CLL Genetics
- IGHV
ASJC Scopus subject areas
- Hematology
- Oncology
- Cancer Research
Cite this
Change in IgHV Mutational Status of CLL Suggests Origin From Multiple Clones. / Osman, Afaf; Gocke, Christopher; Gladstone, Douglas.
In: Clinical Lymphoma, Myeloma and Leukemia, Vol. 17, No. 2, 01.02.2017, p. 97-99.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Change in IgHV Mutational Status of CLL Suggests Origin From Multiple Clones
AU - Osman, Afaf
AU - Gocke, Christopher
AU - Gladstone, Douglas
PY - 2017/2/1
Y1 - 2017/2/1
N2 - Micro-Abstract Immunoglobulin heavy chain mutational status of chronic lymphocytic leukemia is used to predict outcome, and is considered stable over time. We examined mutational status in a 56 patients cohort study, and identified 7 who changed mutational status. This supports the multiclonal nature of chronic lymphocytic leukemia and suggests a cell of origin that has not yet rearranged or is capable of continuing to rearrange and mutate its immunoglobulin genes.
AB - Micro-Abstract Immunoglobulin heavy chain mutational status of chronic lymphocytic leukemia is used to predict outcome, and is considered stable over time. We examined mutational status in a 56 patients cohort study, and identified 7 who changed mutational status. This supports the multiclonal nature of chronic lymphocytic leukemia and suggests a cell of origin that has not yet rearranged or is capable of continuing to rearrange and mutate its immunoglobulin genes.
KW - Cancer stem cell
KW - CLL
KW - CLL Genetics
KW - IGHV
UR - http://www.scopus.com/inward/record.url?scp=85009834517&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85009834517&partnerID=8YFLogxK
U2 - 10.1016/j.clml.2016.11.008
DO - 10.1016/j.clml.2016.11.008
M3 - Article
C2 - 28041846
AN - SCOPUS:85009834517
VL - 17
SP - 97
EP - 99
JO - Clinical Lymphoma, Myeloma and Leukemia
JF - Clinical Lymphoma, Myeloma and Leukemia
SN - 2152-2669
IS - 2
ER -