Abstract
Micro-Abstract Immunoglobulin heavy chain mutational status of chronic lymphocytic leukemia is used to predict outcome, and is considered stable over time. We examined mutational status in a 56 patients cohort study, and identified 7 who changed mutational status. This supports the multiclonal nature of chronic lymphocytic leukemia and suggests a cell of origin that has not yet rearranged or is capable of continuing to rearrange and mutate its immunoglobulin genes.
Original language | English (US) |
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Pages (from-to) | 97-99 |
Number of pages | 3 |
Journal | Clinical Lymphoma, Myeloma and Leukemia |
Volume | 17 |
Issue number | 2 |
DOIs | |
State | Published - Feb 1 2017 |
Keywords
- Cancer stem cell
- CLL
- CLL Genetics
- IGHV
ASJC Scopus subject areas
- Hematology
- Oncology
- Cancer Research