Change in IgHV Mutational Status of CLL Suggests Origin From Multiple Clones

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Abstract

Micro-Abstract Immunoglobulin heavy chain mutational status of chronic lymphocytic leukemia is used to predict outcome, and is considered stable over time. We examined mutational status in a 56 patients cohort study, and identified 7 who changed mutational status. This supports the multiclonal nature of chronic lymphocytic leukemia and suggests a cell of origin that has not yet rearranged or is capable of continuing to rearrange and mutate its immunoglobulin genes.

Original languageEnglish (US)
Pages (from-to)97-99
Number of pages3
JournalClinical Lymphoma, Myeloma and Leukemia
Volume17
Issue number2
DOIs
StatePublished - Feb 1 2017

Keywords

  • Cancer stem cell
  • CLL
  • CLL Genetics
  • IGHV

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

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