Change in IgHV Mutational Status of CLL Suggests Origin From Multiple Clones

Afaf Osman; Christopher Gocke; Douglas Gladstone

doi:10.1016/j.clml.2016.11.008

Change in IgHV Mutational Status of CLL Suggests Origin From Multiple Clones

Afaf Osman, Christopher Gocke, Douglas Gladstone

School of Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

Micro-Abstract Immunoglobulin heavy chain mutational status of chronic lymphocytic leukemia is used to predict outcome, and is considered stable over time. We examined mutational status in a 56 patients cohort study, and identified 7 who changed mutational status. This supports the multiclonal nature of chronic lymphocytic leukemia and suggests a cell of origin that has not yet rearranged or is capable of continuing to rearrange and mutate its immunoglobulin genes.

Original language	English (US)
Pages (from-to)	97-99
Number of pages	3
Journal	Clinical Lymphoma, Myeloma and Leukemia
Volume	17
Issue number	2
DOIs	https://doi.org/10.1016/j.clml.2016.11.008
State	Published - Feb 1 2017

Keywords

Cancer stem cell
CLL
CLL Genetics
IGHV

ASJC Scopus subject areas

Hematology
Oncology
Cancer Research

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title = "Change in IgHV Mutational Status of CLL Suggests Origin From Multiple Clones",

abstract = "Micro-Abstract Immunoglobulin heavy chain mutational status of chronic lymphocytic leukemia is used to predict outcome, and is considered stable over time. We examined mutational status in a 56 patients cohort study, and identified 7 who changed mutational status. This supports the multiclonal nature of chronic lymphocytic leukemia and suggests a cell of origin that has not yet rearranged or is capable of continuing to rearrange and mutate its immunoglobulin genes.",

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AU - Gladstone, Douglas

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N2 - Micro-Abstract Immunoglobulin heavy chain mutational status of chronic lymphocytic leukemia is used to predict outcome, and is considered stable over time. We examined mutational status in a 56 patients cohort study, and identified 7 who changed mutational status. This supports the multiclonal nature of chronic lymphocytic leukemia and suggests a cell of origin that has not yet rearranged or is capable of continuing to rearrange and mutate its immunoglobulin genes.

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