@article{e90217b296134b10a401042c63d47b9a,
title = "Change in Circulating Undercarboxylated Osteocalcin (ucOCN) Is Associated with Fat Accumulation in HIV-Seropositive Women",
abstract = "Background: Bone mineral density loss and fat accumulation are common in people living with HIV. The bone-derived hormone, undercarboxylated osteocalcin (ucOCN) regulates fat metabolism. We investigated the relationship between ucOCN change and body fat change among perimenopausal/postmenopausal HIV-seronegative and HIV-seropositive women on long-term antiretrovirals.Methods: Perimenopausal and postmenopausal women enrolled in the Women's Interagency HIV Study MSK substudy underwent trunk and total fat assessment by dual energy x-ray absorptiometry (DXA) at study enrollment (index visit) and again 2 years later. Circulating ucOCN and cOCN were also measured at the index and 2-year visits. The correlation between the 2-year change in ucOCN and cOCN and change in trunk and total fat was assessed as a function of HIV serostatus using linear regression modeling. Multivariate linear regression assessed the association between ucOCN and cOCN change and total and trunk fat change after adjusting for sociodemographic variables. Linear regression models restricted to HIV-seropositive women were performed to examine the contributions of HIV-specific factors (index CD4 count, viral load, and combined antiretroviral therapy use) on the associations.Results: Increased ucOCN over the 2-year follow-up was associated with less trunk and total fat accumulation in models adjusting for HIV serostatus and participants sociodemographics, whereas there was no association with cOCN and the fat parameters. None of the HIV-specific factors evaluated influenced the association between ucOCN and fat parameters.Conclusion: The current study suggests that increases in ucOCN are associated with decreased fat accumulation in HIV-seronegative and HIV-seropositive postmenopausal women on long-term antiretroviral therapy. ",
keywords = "HIV, body composition, bone, cART, osteocalcin",
author = "Olali, {Arnold Z.} and Anjali Sharma and Qiuhu Shi and Hoover, {Donald R.} and Weber, {Kathleen M.} and French, {Audrey L.} and McKay, {Heather S.} and Tien, {Phyllis C.} and Lena Al-Harthi and Yin, {Michael T.} and Ross, {Ryan D.}",
note = "Funding Information: Supported by the Rush University Scientific Leadership Council by a musculoskeletal pilot grant (R.D.R.), the National Institutes of Health through Grants K23AR061993 (A.S.), and the National Center for Advancing Translation Sciences, through Grant Number UL1TR001873. The contents of this publication are solely the responsibility of the authors and do not represent the official views of the National Institutes of Health (NIH). Data in this article were collected by the Women's Interagency HIV Study, now the MACS/WIHS Combined Cohort Study (MWCCS), and the National Institutes of Health through Grants R01AI095089 (M.T.Y.). Additional biomarker testing and data analyses for this article were supported by National Institute Of Allergy And Infectious Diseases (NIAID) funding to the Chicago WIHS; 5U01AI034992-24 (Mardge Cohen, Audrey French). WIHS/MWCCS (Principal Investigators) for this project/article include: Bronx CRS (Kathryn Anastos and Anjali Sharma), U01-HL146204; U01-HL146193; Chicago-Cook County CRS (Mardge Cohen and Audrey French), U01-HL146240; Connie Wofsy Women's HIV Study, Northern California CRS (Bradley Aouizerat and Phyllis Tien), U01-HL146242; Data and biomarkers for this article were supported by funding from National Institute Of Allergy And Infectious Diseases (NIAID); the MWCCS is funded primarily by the National Heart, Lung, and Blood Institute (NHLBI), with additional cofunding from the Eunice Kennedy Shriver National Institute Of Child Health & Human Development (NICHD), National Institute Of Allergy And Infectious Diseases (NIAID), National Human Genome Research Institute (NHGRI), National Institute On Aging (NIA), National Institute Of Dental & Craniofacial Research (NIDCR), National Institute Of Allergy And Infectious Diseases (NIAID), National Institute Of Neurological Disorders And Stroke (NINDS), National Institute Of Mental Health (NIMH), National Institute On Drug Abuse (NIDA), National Institute Of Nursing Research (NINR), National Cancer Institute (NCI), National Institute on Alcohol Abuse and Alcoholism (NIAAA), National Institute on Deafness and Other Communication Disorders (NIDCD), and National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK). Publisher Copyright: {\textcopyright} 2020 Wolters Kluwer Health, Inc.",
year = "2021",
month = apr,
day = "15",
doi = "10.1097/QAI.0000000000002617",
language = "English (US)",
volume = "86",
pages = "E139--E145",
journal = "Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology",
issn = "1525-4135",
publisher = "Lippincott Williams and Wilkins",
number = "5",
}