TY - JOUR
T1 - Change in choroidal thickness and axial length with change in intraocular pressure after trabeculectomy
AU - Saeedi, Osamah
AU - Pillar, Angelique
AU - Jefferys, Joan
AU - Arora, Karun
AU - Friedman, David
AU - Quigley, Harry
PY - 2014/7
Y1 - 2014/7
N2 - Background/aims: We studied the change in choroidal thickness (CT) and axial length (AL) after intraocular (IOP) changes produced by trabeculectomy. Methods: Twenty-one eyes of 20 patients were studied preoperatively, and then postoperatively at 1 week, 1, 3, and 6 months. Variables measured included IOP, AL, keratometry, refractive error, central corneal thickness, and average CT in the posterior 6 mm centred on the fovea using enhanced depth imaging spectral domain optical coherence tomography (OCT). Results: OCT images in 17 eyes (58 images, preoperatively and postoperatively) were of sufficient quality to determine CT. In every patient, CT increased with IOP lowering postoperatively. For each 1 mm Hg decrease in IOP, there was a mean increase of 3.4 μm in CT (p<0.0001; univariate regression, 95% CI 2.5 to 4.3). This represented a CT increase of 1.7% per mm Hg decrease (p<0.0001; 95% CI 1.3 to 2.0%). AL decreased by 6.8 μm per mm Hg decrease in IOP (p<0.0001, univariate regression, 95% CI 4.9 to 8.6). Conclusions: The dynamic relationship between change in IOP and the state of sclera and choroid was confirmed by sequential measurements in postoperative trabeculectomy patients, providing estimates of the magnitude of choroidal swelling and scleral volume decrease with IOP lowering.
AB - Background/aims: We studied the change in choroidal thickness (CT) and axial length (AL) after intraocular (IOP) changes produced by trabeculectomy. Methods: Twenty-one eyes of 20 patients were studied preoperatively, and then postoperatively at 1 week, 1, 3, and 6 months. Variables measured included IOP, AL, keratometry, refractive error, central corneal thickness, and average CT in the posterior 6 mm centred on the fovea using enhanced depth imaging spectral domain optical coherence tomography (OCT). Results: OCT images in 17 eyes (58 images, preoperatively and postoperatively) were of sufficient quality to determine CT. In every patient, CT increased with IOP lowering postoperatively. For each 1 mm Hg decrease in IOP, there was a mean increase of 3.4 μm in CT (p<0.0001; univariate regression, 95% CI 2.5 to 4.3). This represented a CT increase of 1.7% per mm Hg decrease (p<0.0001; 95% CI 1.3 to 2.0%). AL decreased by 6.8 μm per mm Hg decrease in IOP (p<0.0001, univariate regression, 95% CI 4.9 to 8.6). Conclusions: The dynamic relationship between change in IOP and the state of sclera and choroid was confirmed by sequential measurements in postoperative trabeculectomy patients, providing estimates of the magnitude of choroidal swelling and scleral volume decrease with IOP lowering.
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U2 - 10.1136/bjophthalmol-2013-304433
DO - 10.1136/bjophthalmol-2013-304433
M3 - Article
C2 - 24627248
AN - SCOPUS:84902368966
SN - 0007-1161
VL - 98
SP - 976
EP - 979
JO - British Journal of Ophthalmology
JF - British Journal of Ophthalmology
IS - 7
ER -