Challenges to "classic" esophageal candidiasis: Looks are usually deceiving

Mohammed I. Alsomali, Michael A. Arnold, Wendy L. Frankel, Rondell P. Graham, Phil A. Hart, Dora M. Lam-Himlin, Bita V. Naini, Lysandra Voltaggio, Christina A. Arnold

Research output: Contribution to journalArticle

Abstract

Objectives: We undertook the first case control study of histologically confirmed esophageal candidiasis (EC). Methods: A computer search from July 2012 through February 2015 identified 1, 011 esophageal specimens, including 40 cases of EC and 20 controls. Results: The EC incidence was 5.2%; it was associated with immunosuppression and endoscopic white plaques and breaks. Smoking was a predisposing factor, and alcohol was protective. EC had no unique symptoms, and 54% of endoscopic reports did not suspect EC. Important histologic clues included superficial and detached fragments of desquamated and hyper-pink parakeratosis, acute inflammation, intraepithelial lymphocytosis, dead keratinocytes, and bacterial overgrowth. Thirty percent had no neutrophilic infiltrate. Pseudohyphae were seen on H&E in 92.5% (n=37/ 40). "Upfront" periodic acid-Schiff with diastase (PAS/D) on all esophageal specimens would have generated $68, 333.49 in patient charges. Our targeted PAS/D strategy resulted in $13, 044.87 in patient charges (cost saving=80.9%, $55, 288.62). Conclusions: We describe the typical morphology of EC and recommend limiting PAS/D to cases where the organisms are not readily identifiable on H&E and with at least one of the following: (1) ulcer, (2) suspicious morphology, and/or (3) clinical impression of EC.

Original languageEnglish (US)
Pages (from-to)33-42
Number of pages10
JournalAmerican Journal of Clinical Pathology
Volume147
Issue number1
DOIs
StatePublished - 2017

Fingerprint

Candidiasis
Periodic Acid
Amylases
Parakeratosis
Lymphocytosis
Keratinocytes
Causality
Immunosuppression
Ulcer
Case-Control Studies
Smoking
Alcohols
Inflammation
Costs and Cost Analysis
Incidence

Keywords

  • Desquamated
  • Esophageal candidiasis (EC)
  • Hyper-pink
  • Parakeratosis
  • Periodic acid-Schiff with diastase (PAS/D)
  • Pseudohyphae

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Alsomali, M. I., Arnold, M. A., Frankel, W. L., Graham, R. P., Hart, P. A., Lam-Himlin, D. M., ... Arnold, C. A. (2017). Challenges to "classic" esophageal candidiasis: Looks are usually deceiving. American Journal of Clinical Pathology, 147(1), 33-42. https://doi.org/10.1093/AJCP/AQW210

Challenges to "classic" esophageal candidiasis : Looks are usually deceiving. / Alsomali, Mohammed I.; Arnold, Michael A.; Frankel, Wendy L.; Graham, Rondell P.; Hart, Phil A.; Lam-Himlin, Dora M.; Naini, Bita V.; Voltaggio, Lysandra; Arnold, Christina A.

In: American Journal of Clinical Pathology, Vol. 147, No. 1, 2017, p. 33-42.

Research output: Contribution to journalArticle

Alsomali, MI, Arnold, MA, Frankel, WL, Graham, RP, Hart, PA, Lam-Himlin, DM, Naini, BV, Voltaggio, L & Arnold, CA 2017, 'Challenges to "classic" esophageal candidiasis: Looks are usually deceiving', American Journal of Clinical Pathology, vol. 147, no. 1, pp. 33-42. https://doi.org/10.1093/AJCP/AQW210
Alsomali MI, Arnold MA, Frankel WL, Graham RP, Hart PA, Lam-Himlin DM et al. Challenges to "classic" esophageal candidiasis: Looks are usually deceiving. American Journal of Clinical Pathology. 2017;147(1):33-42. https://doi.org/10.1093/AJCP/AQW210
Alsomali, Mohammed I. ; Arnold, Michael A. ; Frankel, Wendy L. ; Graham, Rondell P. ; Hart, Phil A. ; Lam-Himlin, Dora M. ; Naini, Bita V. ; Voltaggio, Lysandra ; Arnold, Christina A. / Challenges to "classic" esophageal candidiasis : Looks are usually deceiving. In: American Journal of Clinical Pathology. 2017 ; Vol. 147, No. 1. pp. 33-42.
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