Challenges of Conducting a Placebo-Controlled Trial for Dysmenorrhea in Adolescents

Anne R. Davis, Lauren M. Osborne, Katharine J. O'Connell, Carolyn L. Westhoff

Research output: Contribution to journalArticlepeer-review

Abstract

We recruited adolescents to study oral contraceptives versus placebo for dysmenorrhea. We anticipated high discontinuation and concerns about safety, side effects, and sexual behavior. Treatment discontinuation (11%) and loss to follow-up (1%) were lower than expected. The most common reason for nonenrollment was logistical issues (63%). Most participants remained abstinent.

Original languageEnglish (US)
Pages (from-to)607-609
Number of pages3
JournalJournal of Adolescent Health
Volume39
Issue number4
DOIs
StatePublished - Oct 2006
Externally publishedYes

Keywords

  • Adolescents
  • Dysmenorrhea
  • Oral contraception

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Public Health, Environmental and Occupational Health
  • Psychiatry and Mental health

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