Challenges implicit to gene discovery research in the control of ventilation during hypoxia

S. E. Soutiere, C. G. Tankersley

Research output: Contribution to journalArticle

Abstract

Soutiere and Tankersley. Challenges Implicit to Gene Discovery Research in the Control of Ventilation during Hypoxia. High Alt Med Biol 2:191-200, 2001.-Appointing physiological function to specific genetic determinants requires a systems physiologist to consider ways of assessing precise phenotypic mechanisms. The integration of ventilation, metabolism and thermoregulation, for example, is very complex and may differ among small and large mammalian species. This challenge is particularly applicable to the study of short- and long-term adaptation of these systems to hypoxic exposure associated with high altitude. Our laboratory has initiated a research effort to dissect the complexity of hypoxic adaptation using traditional quantitative genetic analysis and contemporary DNA genotyping techniques. Although the current evidence in murine models demonstrates that specific genes influence control of hypoxic ventilatory responses (HVR), the relevance of these determinants to human adaptation to altitude remains open to exploration. Our review discusses the progress and uncertainties associated with assigning a genetic basis to variation in acute and chronic HVR.

Original languageEnglish (US)
Pages (from-to)191-200
Number of pages10
JournalHigh Altitude Medicine and Biology
Volume2
Issue number2
DOIs
StatePublished - Aug 6 2001

Keywords

  • Gene-environment interactions
  • Hypoxic hypometabolism
  • Hypoxic hypoventilation
  • Lung structure and function
  • Quantitative genetic traits

ASJC Scopus subject areas

  • Physiology
  • Public Health, Environmental and Occupational Health

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