@article{b2ead7117bea47e9a0e59eae7032cf51,
title = "Challenges and opportunities for neuroimaging in young patients with traumatic brain injury: a coordinated effort towards advancing discovery from the ENIGMA pediatric moderate/severe TBI group",
abstract = "Traumatic brain injury (TBI) is a major cause of death and disability in children in both developed and developing nations. Children and adolescents suffer from TBI at a higher rate than the general population, and specific developmental issues require a unique context since findings from adult research do not necessarily directly translate to children. Findings in pediatric cohorts tend to lag behind those in adult samples. This may be due, in part, both to the smaller number of investigators engaged in research with this population and may also be related to changes in safety laws and clinical practice that have altered length of hospital stays, treatment, and access to this population. The ENIGMA (Enhancing NeuroImaging Genetics through Meta-Analysis) Pediatric Moderate/Severe TBI (msTBI) group aims to advance research in this area through global collaborative meta-analysis of neuroimaging data. In this paper, we discuss important challenges in pediatric TBI research and opportunities that we believe the ENIGMA Pediatric msTBI group can provide to address them. With the paucity of research studies examining neuroimaging biomarkers in pediatric patients with TBI and the challenges of recruiting large numbers of participants, collaborating to improve statistical power and to address technical challenges like lesions will significantly advance the field. We conclude with recommendations for future research in this field of study.",
keywords = "ENIGMA, Moderate-severe TBI, Neuroimaging, Pediatric, traumatic brain injury (TBI)",
author = "Dennis, {Emily L.} and Karen Caeyenberghs and Asarnow, {Robert F.} and Talin Babikian and Brenda Bartnik-Olson and Bigler, {Erin D.} and Anthony Figaji and Giza, {Christopher C.} and Goodrich-Hunsaker, {Naomi J.} and Hodges, {Cooper B.} and Hoskinson, {Kristen R.} and Marsh K{\"o}nigs and Levin, {Harvey S.} and Lindsey, {Hannah M.} and Abigail Livny and Max, {Jeffrey E.} and Merkley, {Tricia L.} and Newsome, {Mary R.} and Alexander Olsen and Ryan, {Nicholas P.} and Spruiell, {Matthew S.} and Suskauer, {Stacy J.} and Thomopoulos, {Sophia I.} and Ware, {Ashley L.} and Watson, {Christopher G.} and Wheeler, {Anne L.} and Yeates, {Keith Owen} and Zielinski, {Brandon A.} and Thompson, {Paul M.} and Tate, {David F.} and Wilde, {Elisabeth A.}",
note = "Funding Information: We wish to acknowledge multiple funding sources, including the following: K99 NS096116 to Dr. Dennis, NHMRC Career Development Fellowship and an ACURF Program grant by the Australian Catholic University (ACU) to Dr. Caeyenberghs, NRF SARChI Chair of Clinical Neurosciences to Dr. Figaji, NICHD R43HD09703901 to Dr. Levin, R01 HD088438 to Dr. Max, and U54 EB020403, R01 MH116147, R56 AG058854, P41 EB015922, R01 MH111671 to Dr. Thompson. Dr. Yeates is supported by the Ronald and Irene Ward Chair in Pediatric Brain Injury, funded by the Alberta Children's Hospital Foundation. The authors wish to acknowledge the leadership of Dr. Paul Thompson (ENIGMA PI) as well as the leadership of Drs. Frank Hillary, Alexander Olsen, Inga Koerte, David Baron, Alexander Lin, Brenda Bartnik-Olson, Carrie Esopenko, and Neda Jahanshad, as well as ENIGMA support personnel and all working group members and contributors. We alos wish to acknowledge the constructive feedback and suggestions of anonymous reviewers. Finally, we wish to acknowledge the participation of the children and family members and the efforts of our many colleagues that make this work possible. Publisher Copyright: {\textcopyright} 2020, Springer Science+Business Media, LLC, part of Springer Nature.",
year = "2021",
month = apr,
doi = "10.1007/s11682-020-00363-x",
language = "English (US)",
volume = "15",
pages = "555--575",
journal = "Brain Imaging and Behavior",
issn = "1931-7557",
publisher = "Springer New York",
number = "2",
}