Challenges and opportunities for hepatitis C drug development in HIV-hepatitis C virus-co-infected patients

Vincent Soriano, Kenneth E. Sherman, Juergen Rockstroh, Douglas Dieterich, David Back, Mark Sulkowski, Marion Peters

Research output: Contribution to journalReview article

Abstract

The approval of the first direct-acting antivirals (DAAs) against the hepatitis C virus (HCV) has been eagerly expected for treating chronic hepatitis C in HIV individuals given that progression to cirrhosis and end-stage liver disease occurs faster in the co-infected population. The appropriate and judicious use of DAAs may provide cure to a large number of HIV-HCV patients. On the contrary, the widespread use of DAAs will occasionally be off-label or under unsatisfactory medical conditions, which may result in undesirable toxicities, drug interactions or selection of drug resistance in HCV. As a result of using first-generation DAAs in HIV-HCV-co-infected patients, a growing proportion of the remaining hepatitis C individuals will be those harboring non-HCV 1 genotypes or drug-resistant HCV variants. Over time, the largest reservoir of HCV genotype 1 patients will accumulate in resource-poor nations where access to hepatitis C therapy has been elusive and HIV treatment remains the primary health issue for the co-infected population.

Original languageEnglish (US)
Pages (from-to)2197-2208
Number of pages12
JournalAIDS
Volume25
Issue number18
DOIs
StatePublished - Nov 28 2011

Keywords

  • HIV
  • boceprevir
  • co-infection
  • direct-acting antivirals
  • drug resistance
  • hepatitis C
  • liver
  • telaprevir

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Infectious Diseases

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