Abstract
Xenograft models are still the backbone of translational research, but inherent weaknesses in this model contribute to the low rates of bench-to-bed translation in cancer research. This chapter discusses these limitations and outlines areas where patient-derived xenograft models may offer advantages for use in cancer research.
Original language | English (US) |
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Title of host publication | Patient Derived Tumor Xenograft Models |
Subtitle of host publication | Promise, Potential and Practice |
Publisher | Elsevier Inc. |
Pages | 25-36 |
Number of pages | 12 |
ISBN (Electronic) | 9780128040614 |
ISBN (Print) | 9780128040102 |
DOIs | |
State | Published - 2017 |
Keywords
- Animal models
- Cancer
- Disease models
- Mice
- Xenograft
ASJC Scopus subject areas
- Medicine(all)