Challenges and limitations of mouse xenograft models of cancer

B. W. Simons; C. Brayton

doi:10.1016/B978-0-12-804010-2.00003-5

Challenges and limitations of mouse xenograft models of cancer

B. W. Simons, C. Brayton

School of Medicine

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Xenograft models are still the backbone of translational research, but inherent weaknesses in this model contribute to the low rates of bench-to-bed translation in cancer research. This chapter discusses these limitations and outlines areas where patient-derived xenograft models may offer advantages for use in cancer research.

Original language	English (US)
Title of host publication	Patient Derived Tumor Xenograft Models
Subtitle of host publication	Promise, Potential and Practice
Publisher	Elsevier Inc.
Pages	25-36
Number of pages	12
ISBN (Electronic)	9780128040614
ISBN (Print)	9780128040102
DOIs	https://doi.org/10.1016/B978-0-12-804010-2.00003-5
State	Published - 2017

Keywords

Animal models
Cancer
Disease models
Mice
Xenograft

ASJC Scopus subject areas

Medicine(all)

Access to Document

10.1016/B978-0-12-804010-2.00003-5

Cite this

@inbook{c60bed660425406ba39f61c278084d53,

title = "Challenges and limitations of mouse xenograft models of cancer",

abstract = "Xenograft models are still the backbone of translational research, but inherent weaknesses in this model contribute to the low rates of bench-to-bed translation in cancer research. This chapter discusses these limitations and outlines areas where patient-derived xenograft models may offer advantages for use in cancer research.",

keywords = "Animal models, Cancer, Disease models, Mice, Xenograft",

author = "Simons, {B. W.} and C. Brayton",

year = "2017",

doi = "10.1016/B978-0-12-804010-2.00003-5",

language = "English (US)",

isbn = "9780128040102",

pages = "25--36",

booktitle = "Patient Derived Tumor Xenograft Models",

publisher = "Elsevier Inc.",

}

TY - CHAP

T1 - Challenges and limitations of mouse xenograft models of cancer

AU - Simons, B. W.

AU - Brayton, C.

PY - 2017

Y1 - 2017

N2 - Xenograft models are still the backbone of translational research, but inherent weaknesses in this model contribute to the low rates of bench-to-bed translation in cancer research. This chapter discusses these limitations and outlines areas where patient-derived xenograft models may offer advantages for use in cancer research.

AB - Xenograft models are still the backbone of translational research, but inherent weaknesses in this model contribute to the low rates of bench-to-bed translation in cancer research. This chapter discusses these limitations and outlines areas where patient-derived xenograft models may offer advantages for use in cancer research.

KW - Animal models

KW - Cancer

KW - Disease models

KW - Mice

KW - Xenograft

UR - http://www.scopus.com/inward/record.url?scp=85020661834&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85020661834&partnerID=8YFLogxK

U2 - 10.1016/B978-0-12-804010-2.00003-5

DO - 10.1016/B978-0-12-804010-2.00003-5

M3 - Chapter

AN - SCOPUS:85020661834

SN - 9780128040102

SP - 25

EP - 36

BT - Patient Derived Tumor Xenograft Models

PB - Elsevier Inc.

ER -

Challenges and limitations of mouse xenograft models of cancer

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this