Challenges and limitations of mouse xenograft models of cancer

B. W. Simons, C. Brayton

Research output: Chapter in Book/Report/Conference proceedingChapter

4 Scopus citations


Xenograft models are still the backbone of translational research, but inherent weaknesses in this model contribute to the low rates of bench-to-bed translation in cancer research. This chapter discusses these limitations and outlines areas where patient-derived xenograft models may offer advantages for use in cancer research.

Original languageEnglish (US)
Title of host publicationPatient Derived Tumor Xenograft Models
Subtitle of host publicationPromise, Potential and Practice
PublisherElsevier Inc.
Number of pages12
ISBN (Electronic)9780128040614
ISBN (Print)9780128040102
StatePublished - 2017


  • Animal models
  • Cancer
  • Disease models
  • Mice
  • Xenograft

ASJC Scopus subject areas

  • Medicine(all)


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