Abstract
Xenograft models are still the backbone of translational research, but inherent weaknesses in this model contribute to the low rates of bench-to-bed translation in cancer research. This chapter discusses these limitations and outlines areas where patient-derived xenograft models may offer advantages for use in cancer research.
| Original language | English (US) |
|---|---|
| Title of host publication | Patient Derived Tumor Xenograft Models |
| Subtitle of host publication | Promise, Potential and Practice |
| Publisher | Elsevier Inc. |
| Pages | 25-36 |
| Number of pages | 12 |
| ISBN (Electronic) | 9780128040614 |
| ISBN (Print) | 9780128040102 |
| DOIs | |
| State | Published - Oct 25 2016 |
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Keywords
- Animal models
- Cancer
- Disease models
- Mice
- Xenograft
ASJC Scopus subject areas
- Medicine(all)
Cite this
Challenges and limitations of mouse xenograft models of cancer. / Simons, B. W.; Brayton, Cory.
Patient Derived Tumor Xenograft Models: Promise, Potential and Practice. Elsevier Inc., 2016. p. 25-36.Research output: Chapter in Book/Report/Conference proceeding › Chapter
}
TY - CHAP
T1 - Challenges and limitations of mouse xenograft models of cancer
AU - Simons, B. W.
AU - Brayton, Cory
PY - 2016/10/25
Y1 - 2016/10/25
N2 - Xenograft models are still the backbone of translational research, but inherent weaknesses in this model contribute to the low rates of bench-to-bed translation in cancer research. This chapter discusses these limitations and outlines areas where patient-derived xenograft models may offer advantages for use in cancer research.
AB - Xenograft models are still the backbone of translational research, but inherent weaknesses in this model contribute to the low rates of bench-to-bed translation in cancer research. This chapter discusses these limitations and outlines areas where patient-derived xenograft models may offer advantages for use in cancer research.
KW - Animal models
KW - Cancer
KW - Disease models
KW - Mice
KW - Xenograft
UR - http://www.scopus.com/inward/record.url?scp=85020661834&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85020661834&partnerID=8YFLogxK
U2 - 10.1016/B978-0-12-804010-2.00003-5
DO - 10.1016/B978-0-12-804010-2.00003-5
M3 - Chapter
AN - SCOPUS:85020661834
SN - 9780128040102
SP - 25
EP - 36
BT - Patient Derived Tumor Xenograft Models
PB - Elsevier Inc.
ER -