Challenges and limitations of mouse xenograft models of cancer

B. W. Simons; C. Brayton

doi:10.1016/B978-0-12-804010-2.00003-5

Challenges and limitations of mouse xenograft models of cancer

B. W. Simons, C. Brayton

School of Medicine

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Xenograft models are still the backbone of translational research, but inherent weaknesses in this model contribute to the low rates of bench-to-bed translation in cancer research. This chapter discusses these limitations and outlines areas where patient-derived xenograft models may offer advantages for use in cancer research.

Original language	English (US)
Title of host publication	Patient Derived Tumor Xenograft Models
Subtitle of host publication	Promise, Potential and Practice
Publisher	Elsevier Inc.
Pages	25-36
Number of pages	12
ISBN (Electronic)	9780128040614
ISBN (Print)	9780128040102
DOIs	https://doi.org/10.1016/B978-0-12-804010-2.00003-5
State	Published - 2017

Keywords

Animal models
Cancer
Disease models
Mice
Xenograft

ASJC Scopus subject areas

Medicine(all)

Access to Document

10.1016/B978-0-12-804010-2.00003-5

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