CFH, VEGF, and PEDF genotypes and the response to intravitreous injection of bevacizumab for the treatment of age-related macular degeneration

Daisuke Imai, Keisuke Mori, Kuniko Horie-Inoue, Peter L. Gehlbach, Takuya Awata, Satoshi Inoue, Shin Yoneya

Research output: Contribution to journalArticlepeer-review

Abstract

We determined whether there is an association between complement factor H (CFH), high-temperature requirement A-1 (HTRA1), vascular endothelial growth factor (VEGF), and pigment epithelium-derived factor (PEDF) genotypes and the response to treatment with a single intravitreous injection of bevacizumab for agerelated macular degeneration (AMD). Eighty-three patients with exudative AMD treated by bevacizumab injection were genotyped for three single nucleotide polymorphisms (SNPs; rs800292, rs1061170, rs1410996) in the CFH gene, a rs11200638-SNP in the HTRA1 gene, three SNPs (rs699947, rs1570360, rs2010963) in the VEGF gene, and four SNPs (rs12150053, rs12948385, rs9913583, rs1136287) in the PEDF gene using a TaqMan assay. The CT genotype (heterozygous) of CFH-rs1061170 was more frequently represented in nonresponders in vision than TT genotypes (nonrisk allele homozygous) at the time points of 1 and 3 months, while there was no CC genotype (risk allele homozygous) in our study cohort (p=7.66 × 10-3, 7.83 × 10-3, respectively). VEGF-rs699947 was also associated with vision changes at 1 month and PEDF-rs1136287 at 3 months (p=5.11 × 10-3, 2.05 × 10- 2, respectively). These variants may be utilized for genetic biomarkers to estimate visual outcomes in the response to intravitreal bevacizumab treatment for AMD.

Original languageEnglish (US)
Pages (from-to)53-59
Number of pages7
JournalJournal of Ocular Biology, Diseases, and Informatics
Volume3
Issue number2
DOIs
StatePublished - Jun 1 2010

Keywords

  • Age-related macular degeneration
  • Bevacizumab
  • Complement factor H
  • Genetic biomarker
  • High-temperature requirement A-1
  • Pigment epitheliumderived factor
  • Vascular endothelial growth factor

ASJC Scopus subject areas

  • Ophthalmology
  • Genetics

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