CFH, C3 and ARMS2 are significant risk loci for susceptibility but not for disease progression of geographic atrophy due to AMD

Hendrik P.N. Scholl, Monika Fleckenstein, Lars G. Fritsche, Steffen Schmitz-Valckenberg, Arno Göbel, Christine Adrion, Christine Herold, Claudia N. Keilhauer, Friederike Mackensen, Andreas Mößner, Daniel Pauleikhoff, Andreas W.A. Weinberger, Ulrich Mansmann, Frank G. Holz, Tim Becker, Bernhard H.F. Weber

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Abstract

Background: Age-related macular degeneration (AMD) is a prevalent cause of blindness in Western societies. Variants in the genes encoding complement factor H (CFH), complement component 3 (C3) and age-related maculopathy susceptibility 2 (ARMS2) have repeatedly been shown to confer significant risks for AMD; however, their role in disease progression and thus their potential relevance for interventional therapeutic approaches remains unknown. Methodology/Principal Findings: Here, we analyzed association between variants in CFH, C3 and ARMS2 and disease progression of geographic atrophy (GA) due to AMD. A quantitative phenotype of disease progression was computed based on longitudinal observations by fundus autofluorescence imaging. In a subset of 99 cases with pure bilateral GA, variants in CFH (Y402H), C3 (R102G), and ARMS2 (A69S) are associated with disease (P=1.6×10-9, 3.2×10-3, and P=2.6×10-12, respectively) when compared to 612 unrelated healthy control individuals. In cases, median progression rate of GA over a mean follow-up period of 3.0 years was 1.61 mm2/ year with high concordance between fellow eyes. No association between the progression rate and any of the genetic risk variants at the three loci was observed (P>0.13). Conclusions/Significance: This study confirms that variants at CFH, C3, and ARMS2 confer significant risks for GA due to AMD. In contrast, our data indicate no association of these variants with disease progression which may have important implications for future treatment strategies. Other, as yet unknown susceptibilities may influence disease progression.

Original languageEnglish (US)
Article numbere7418
JournalPloS one
Volume4
Issue number10
DOIs
StatePublished - Oct 12 2009

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ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)
  • General

Cite this

Scholl, H. P. N., Fleckenstein, M., Fritsche, L. G., Schmitz-Valckenberg, S., Göbel, A., Adrion, C., Herold, C., Keilhauer, C. N., Mackensen, F., Mößner, A., Pauleikhoff, D., Weinberger, A. W. A., Mansmann, U., Holz, F. G., Becker, T., & Weber, B. H. F. (2009). CFH, C3 and ARMS2 are significant risk loci for susceptibility but not for disease progression of geographic atrophy due to AMD. PloS one, 4(10), [e7418]. https://doi.org/10.1371/journal.pone.0007418