Cervical neoplasia and repeated positivity of human papillomavirus infection in human immunodeficiency virus-seropositive and -seronegative women

Linda Ahdieh, Alvaro Munoz, David Vlahov, Cornelia L Trimble, Lauren A. Timpson, Keerti Shah

Research output: Contribution to journalArticle

Abstract

Increased risk for cervical intraepithelial neoplasia (CIN) in human immunodeficiency virus (HIV)-infected women may be explained by repeated positivity of human papillomavirus (HPV) infection facilitated by HIV infection and related immunosuppression. As part of a longitudinal study with semiannual examinations, 268 women in Baltimore, Maryland (of whom 184 were HIV+), provided 1,426 cervicovaginal lavage specimens tested for HPV DNA by a polymerase chain reaction-based assay between 1992 and 1998. HPV positivity and time to HPV clearance according to HIV serostatus and CD4+ cell count were compared using models for correlated binary data and survival analysis. Of the 187 participants who had at least one positive measurement, the probability of subsequent HPV positivity among HIV- women and HIV+ women with CD4+ ≥200 and

Original languageEnglish (US)
Pages (from-to)1148-1157
Number of pages10
JournalAmerican Journal of Epidemiology
Volume151
Issue number12
StatePublished - Jun 15 2000

Fingerprint

Papillomavirus Infections
HIV
Neoplasms
Baltimore
Cervical Intraepithelial Neoplasia
Therapeutic Irrigation
Virus Diseases
DNA-Directed DNA Polymerase
CD4 Lymphocyte Count
Survival Analysis
Immunosuppression
Longitudinal Studies
HIV-1
Polymerase Chain Reaction

Keywords

  • Cervical intraepithelial neoplasia
  • HIV
  • Human
  • Immunosuppression
  • Papillomavirus

ASJC Scopus subject areas

  • Epidemiology

Cite this

Cervical neoplasia and repeated positivity of human papillomavirus infection in human immunodeficiency virus-seropositive and -seronegative women. / Ahdieh, Linda; Munoz, Alvaro; Vlahov, David; Trimble, Cornelia L; Timpson, Lauren A.; Shah, Keerti.

In: American Journal of Epidemiology, Vol. 151, No. 12, 15.06.2000, p. 1148-1157.

Research output: Contribution to journalArticle

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