Cervical dystonia: A neural integrator disorder

Aasef G. Shaikh, David Samuel Zee, J. Douglas Crawford, Hyder A. Jinnah

Research output: Contribution to journalArticle

Abstract

Ocular motor neural integrators ensure that eyes are held steady in straight-ahead and eccentric positions of gaze. Abnormal function of the ocular motor neural integrator leads to centripetal drifts of the eyes with consequent gaze-evoked nystagmus. In 2002 a neural integrator, analogous to that in the ocular motor system, was proposed for the control of head movements. Recently, a counterpart of gaze-evoked eye nystagmus was identified for head movements; in which the head could not be held steady in eccentric positions on the trunk. These findings lead to a novel pathophysiological explanation in cervical dystonia, which proposed that the abnormalities of head movements stem from a malfunctioning head neural integrator, either intrinsically or as a result of impaired cerebellar, basal ganglia, or peripheral feedback. Here we briefly recapitulate the history of the neural integrator for eye movements, then further develop the idea of a neural integrator for head movements, and finally discuss its putative role in cervical dystonia. We hypothesize that changing the activity in an impaired head neural integrator, by modulating feedback, could treat dystonia.

Original languageEnglish (US)
Pages (from-to)2590-2599
Number of pages10
JournalBrain
Volume139
Issue number10
DOIs
StatePublished - Oct 1 2016

Keywords

  • cerebellum
  • integrator
  • midbrain
  • nystagmus
  • tremor

ASJC Scopus subject areas

  • Medicine(all)
  • Arts and Humanities (miscellaneous)
  • Clinical Neurology

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  • Cite this

    Shaikh, A. G., Zee, D. S., Crawford, J. D., & Jinnah, H. A. (2016). Cervical dystonia: A neural integrator disorder. Brain, 139(10), 2590-2599. https://doi.org/10.1093/brain/aww141