Cervical dysplasia on cervicovaginal papanicolaou smear among HIV-1- infected pregnant and nonpregnant women

Pamela Stratton, Prabodh Gupta, Katherine Riester, Harold Fox, Carmen Zorrilla, Ruth Tuomala, Nancy Eriksen, Mark Vajaranant, Howard Minkoff, Mary Glenn Fowler

Research output: Contribution to journalArticle

Abstract

Objective: To assess the association of squamous intraepithelial lesions (SIL) on cervicovaginal Papanicolaou (Pap) smear among women infected with HIV-1 and their pregnancy status, and historical and clinical factors. Methods: Study enrollment Pap smears of 452 pregnant and 126 nonpregnant HIV- infected women had cytologic evaluation. The rates of SIL were compared with pregnancy status, immunosuppression, presence of sexually transmitted diseases (STDs) and demographic features. Results: Rates of low grade SIL were similar for pregnant and nonpregnant HIV-1-infected women (17% and 23.8%, respectively; p = .09). Of them, 12 women, 9 pregnant and 3 nonpregnant, had high grade SIL. None had invasive cervical cancer. Low CD4 percentage (odds ratio, [OR] = 3.8; 95% confidence interval [CI], 2.0-7.3) and inflammation (OR = 2.8; 95% CI, 1.8-4.3) were associated with SIL. An association between herpes simplex and SIL (OR = 3.3; 95% CI, 1.1-9.5) was less certain due to clinical diagnosis and low prevalence of herpes simplex (17 of 456 women). Conclusions: Pap smears for a cohort of HIV-infected pregnant and nonpregnant women revealed a high prevalence of LGSIL but a low prevalence of HGSIL and no cases of cervical cancer. Although pregnancy may not affect the rate of Pap smear abnormalities, SIL is associated with immunosuppression, cervical inflammation, and herpes simplex. Closer surveillance of HIV-1-infected women with these risk factors may be warranted.

Original languageEnglish (US)
Pages (from-to)300-307
Number of pages8
JournalJournal of Acquired Immune Deficiency Syndromes and Human Retrovirology
Volume20
Issue number3
StatePublished - Mar 1 1999
Externally publishedYes

Fingerprint

Uterine Cervical Dysplasia
Papanicolaou Test
HIV-1
Pregnant Women
Herpes Simplex
Odds Ratio
Confidence Intervals
Uterine Cervical Neoplasms
Pregnancy
Immunosuppression
HIV
Inflammation
Sexually Transmitted Diseases
Squamous Intraepithelial Lesions of the Cervix
Demography

Keywords

  • HIV-infected women
  • Papanicolaou smear
  • Pregnancy
  • Squamous intraepithelial lesions

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Virology

Cite this

Cervical dysplasia on cervicovaginal papanicolaou smear among HIV-1- infected pregnant and nonpregnant women. / Stratton, Pamela; Gupta, Prabodh; Riester, Katherine; Fox, Harold; Zorrilla, Carmen; Tuomala, Ruth; Eriksen, Nancy; Vajaranant, Mark; Minkoff, Howard; Fowler, Mary Glenn.

In: Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology, Vol. 20, No. 3, 01.03.1999, p. 300-307.

Research output: Contribution to journalArticle

Stratton, P, Gupta, P, Riester, K, Fox, H, Zorrilla, C, Tuomala, R, Eriksen, N, Vajaranant, M, Minkoff, H & Fowler, MG 1999, 'Cervical dysplasia on cervicovaginal papanicolaou smear among HIV-1- infected pregnant and nonpregnant women', Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology, vol. 20, no. 3, pp. 300-307.
Stratton, Pamela ; Gupta, Prabodh ; Riester, Katherine ; Fox, Harold ; Zorrilla, Carmen ; Tuomala, Ruth ; Eriksen, Nancy ; Vajaranant, Mark ; Minkoff, Howard ; Fowler, Mary Glenn. / Cervical dysplasia on cervicovaginal papanicolaou smear among HIV-1- infected pregnant and nonpregnant women. In: Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology. 1999 ; Vol. 20, No. 3. pp. 300-307.
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abstract = "Objective: To assess the association of squamous intraepithelial lesions (SIL) on cervicovaginal Papanicolaou (Pap) smear among women infected with HIV-1 and their pregnancy status, and historical and clinical factors. Methods: Study enrollment Pap smears of 452 pregnant and 126 nonpregnant HIV- infected women had cytologic evaluation. The rates of SIL were compared with pregnancy status, immunosuppression, presence of sexually transmitted diseases (STDs) and demographic features. Results: Rates of low grade SIL were similar for pregnant and nonpregnant HIV-1-infected women (17{\%} and 23.8{\%}, respectively; p = .09). Of them, 12 women, 9 pregnant and 3 nonpregnant, had high grade SIL. None had invasive cervical cancer. Low CD4 percentage (odds ratio, [OR] = 3.8; 95{\%} confidence interval [CI], 2.0-7.3) and inflammation (OR = 2.8; 95{\%} CI, 1.8-4.3) were associated with SIL. An association between herpes simplex and SIL (OR = 3.3; 95{\%} CI, 1.1-9.5) was less certain due to clinical diagnosis and low prevalence of herpes simplex (17 of 456 women). Conclusions: Pap smears for a cohort of HIV-infected pregnant and nonpregnant women revealed a high prevalence of LGSIL but a low prevalence of HGSIL and no cases of cervical cancer. Although pregnancy may not affect the rate of Pap smear abnormalities, SIL is associated with immunosuppression, cervical inflammation, and herpes simplex. Closer surveillance of HIV-1-infected women with these risk factors may be warranted.",
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T1 - Cervical dysplasia on cervicovaginal papanicolaou smear among HIV-1- infected pregnant and nonpregnant women

AU - Stratton, Pamela

AU - Gupta, Prabodh

AU - Riester, Katherine

AU - Fox, Harold

AU - Zorrilla, Carmen

AU - Tuomala, Ruth

AU - Eriksen, Nancy

AU - Vajaranant, Mark

AU - Minkoff, Howard

AU - Fowler, Mary Glenn

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N2 - Objective: To assess the association of squamous intraepithelial lesions (SIL) on cervicovaginal Papanicolaou (Pap) smear among women infected with HIV-1 and their pregnancy status, and historical and clinical factors. Methods: Study enrollment Pap smears of 452 pregnant and 126 nonpregnant HIV- infected women had cytologic evaluation. The rates of SIL were compared with pregnancy status, immunosuppression, presence of sexually transmitted diseases (STDs) and demographic features. Results: Rates of low grade SIL were similar for pregnant and nonpregnant HIV-1-infected women (17% and 23.8%, respectively; p = .09). Of them, 12 women, 9 pregnant and 3 nonpregnant, had high grade SIL. None had invasive cervical cancer. Low CD4 percentage (odds ratio, [OR] = 3.8; 95% confidence interval [CI], 2.0-7.3) and inflammation (OR = 2.8; 95% CI, 1.8-4.3) were associated with SIL. An association between herpes simplex and SIL (OR = 3.3; 95% CI, 1.1-9.5) was less certain due to clinical diagnosis and low prevalence of herpes simplex (17 of 456 women). Conclusions: Pap smears for a cohort of HIV-infected pregnant and nonpregnant women revealed a high prevalence of LGSIL but a low prevalence of HGSIL and no cases of cervical cancer. Although pregnancy may not affect the rate of Pap smear abnormalities, SIL is associated with immunosuppression, cervical inflammation, and herpes simplex. Closer surveillance of HIV-1-infected women with these risk factors may be warranted.

AB - Objective: To assess the association of squamous intraepithelial lesions (SIL) on cervicovaginal Papanicolaou (Pap) smear among women infected with HIV-1 and their pregnancy status, and historical and clinical factors. Methods: Study enrollment Pap smears of 452 pregnant and 126 nonpregnant HIV- infected women had cytologic evaluation. The rates of SIL were compared with pregnancy status, immunosuppression, presence of sexually transmitted diseases (STDs) and demographic features. Results: Rates of low grade SIL were similar for pregnant and nonpregnant HIV-1-infected women (17% and 23.8%, respectively; p = .09). Of them, 12 women, 9 pregnant and 3 nonpregnant, had high grade SIL. None had invasive cervical cancer. Low CD4 percentage (odds ratio, [OR] = 3.8; 95% confidence interval [CI], 2.0-7.3) and inflammation (OR = 2.8; 95% CI, 1.8-4.3) were associated with SIL. An association between herpes simplex and SIL (OR = 3.3; 95% CI, 1.1-9.5) was less certain due to clinical diagnosis and low prevalence of herpes simplex (17 of 456 women). Conclusions: Pap smears for a cohort of HIV-infected pregnant and nonpregnant women revealed a high prevalence of LGSIL but a low prevalence of HGSIL and no cases of cervical cancer. Although pregnancy may not affect the rate of Pap smear abnormalities, SIL is associated with immunosuppression, cervical inflammation, and herpes simplex. Closer surveillance of HIV-1-infected women with these risk factors may be warranted.

KW - HIV-infected women

KW - Papanicolaou smear

KW - Pregnancy

KW - Squamous intraepithelial lesions

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