Cervical dysplasia in pregnancy: A multi-institutional evaluation

Amanda N. Fader, Erin K. Alward, Amy Niederhauser, Christina Chirico, Jamie L. Lesnock, Daniel J. Zwiesler, Richard S. Guido, Darla J. Lofgren, Michael A. Gold, Kathleen N. Moore

Research output: Contribution to journalArticle

Abstract

Objective: This study was undertaken to identify the prognostic indicators associated with postpartum regression of cervical dysplasia diagnosed in pregnancy. Study Design: A retrospective cohort study of pregnant women referred for colposcopy from 2004-2007 at four academic centers. Results: One thousand seventy-nine patients were identified. Colposcopic impression by cervical cytology is detailed later in the text. Of patients who underwent biopsy, results correlated with or were less severe than colposcopic impression in 83% with CIN 1 and 56% with CIN 2/3. Fifty-seven percent had follow-up postpartum, with 61% reverting to normal. Resolution of cervical dysplasia was inversely associated with smoking (P = .002). No progression to cancer occurred during pregnancy. Conclusion: Colposcopic impression in pregnancy correlated with cervical biopsy results and postpartum colposcopic findings when performed by expert colposcopists. A high proportion of cervical dysplasia regressed postpartum. Cervical biopsies in pregnancy may not be necessary unless invasive cancer is suspected.

Original languageEnglish (US)
Pages (from-to)113.e1-113.e6
JournalAmerican journal of obstetrics and gynecology
Volume203
Issue number2
DOIs
StatePublished - 2010

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Keywords

  • HSIL
  • cervical dysplasia
  • colposcopy
  • pregnancy

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Cite this

Fader, A. N., Alward, E. K., Niederhauser, A., Chirico, C., Lesnock, J. L., Zwiesler, D. J., Guido, R. S., Lofgren, D. J., Gold, M. A., & Moore, K. N. (2010). Cervical dysplasia in pregnancy: A multi-institutional evaluation. American journal of obstetrics and gynecology, 203(2), 113.e1-113.e6. https://doi.org/10.1016/j.ajog.2010.04.016