Cervical Dedifferentiated Liposarcoma with Meningothelial-Like Whorling

Jeffrey M. Blumberg, Jaroslaw Jedrych, Jose Costa, Benjamin Judson

Research output: Contribution to journalArticlepeer-review


Liposarcomas are the most common soft-tissue sarcoma of adults, but rare in the head and neck. Recently, a subtype of dedifferentiated liposarcoma with meningiothelial-like whorls was reported and we present the first description of such a tumor in the head and neck. A 65 year old male underwent a resection of a calcified retroesophageal mass that was in close relation to the left hemithyroid and recurrent laryngeal nerve. It was resected en bloc with the left thyroid lobe. Initial pathologic evaluation suggested the mass was a schwanomma of the recurrent laryngeal nerve, but positive staining for MDM2 and CDK4 indicated the tumor was a dedifferentiated liposarcoma. Further evaluation elucidated the unique meningothelial-like whorls within the tumor. This case demonstrates dedifferentiated liposarcomas do appear in the head and neck. Furthermore, this is the first report in the head and neck of the mengiothelial-like whorling pattern type of dedifferentiated liposarcoma.

Original languageEnglish (US)
Pages (from-to)476-480
Number of pages5
JournalHead and Neck Pathology
Issue number4
StatePublished - Dec 2012
Externally publishedYes


  • Cervical
  • Dedifferentiated
  • Liposarcoma
  • Meningothelial-like whorls

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Otorhinolaryngology
  • Oncology


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