Cervical cancer: A global health crisis

William Small; Monica A. Bacon; Amishi Bajaj; Linus T. Chuang; Brandon J. Fisher; Matthew M. Harkenrider; Anuja Jhingran; Henry C. Kitchener; Linda R. Mileshkin; Akila N. Viswanathan; David K. Gaffney

doi:10.1002/cncr.30667

Cervical cancer: A global health crisis

William Small, Monica A. Bacon, Amishi Bajaj, Linus T. Chuang, Brandon J. Fisher, Matthew M. Harkenrider, Anuja Jhingran, Henry C. Kitchener, Linda R. Mileshkin, Akila N. Viswanathan, David K. Gaffney

School of Medicine

Research output: Contribution to journal › Review article › peer-review

351 Scopus citations

Abstract

Cervical cancer is the fourth most common malignancy diagnosed in women worldwide. Nearly all cases of cervical cancer result from infection with the human papillomavirus, and the prevention of cervical cancer includes screening and vaccination. Primary treatment options for patients with cervical cancer may include surgery or a concurrent chemoradiotherapy regimen consisting of cisplatin-based chemotherapy with external beam radiotherapy and brachytherapy. Cervical cancer causes more than one quarter of a million deaths per year as a result of grossly deficient treatments in many developing countries. This warrants a concerted global effort to counter the shocking loss of life and suffering that largely goes unreported. This article provides a review of the biology, prevention, and treatment of cervical cancer, and discusses the global cervical cancer crisis and efforts to improve the prevention and treatment of the disease in underdeveloped countries. Cancer 2017;123:2404–12.

Original language	English (US)
Pages (from-to)	2404-2412
Number of pages	9
Journal	Cancer
Volume	123
Issue number	13
DOIs	https://doi.org/10.1002/cncr.30667
State	Published - Jul 1 2017

Keywords

Cervix Cancer Research Network (CCRN)
Gynecological Cancer InterGroup (GCIG)
activism
brachytherapy
cervical cancer
chemotherapy
developing world
human papillomavirus (HPV)
vaccination

ASJC Scopus subject areas

Oncology
Cancer Research

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title = "Cervical cancer: A global health crisis",

abstract = "Cervical cancer is the fourth most common malignancy diagnosed in women worldwide. Nearly all cases of cervical cancer result from infection with the human papillomavirus, and the prevention of cervical cancer includes screening and vaccination. Primary treatment options for patients with cervical cancer may include surgery or a concurrent chemoradiotherapy regimen consisting of cisplatin-based chemotherapy with external beam radiotherapy and brachytherapy. Cervical cancer causes more than one quarter of a million deaths per year as a result of grossly deficient treatments in many developing countries. This warrants a concerted global effort to counter the shocking loss of life and suffering that largely goes unreported. This article provides a review of the biology, prevention, and treatment of cervical cancer, and discusses the global cervical cancer crisis and efforts to improve the prevention and treatment of the disease in underdeveloped countries. Cancer 2017;123:2404–12.",

keywords = "Cervix Cancer Research Network (CCRN), Gynecological Cancer InterGroup (GCIG), activism, brachytherapy, cervical cancer, chemotherapy, developing world, human papillomavirus (HPV), vaccination",

author = "William Small and Bacon, {Monica A.} and Amishi Bajaj and Chuang, {Linus T.} and Fisher, {Brandon J.} and Harkenrider, {Matthew M.} and Anuja Jhingran and Kitchener, {Henry C.} and Mileshkin, {Linda R.} and Viswanathan, {Akila N.} and Gaffney, {David K.}",

note = "Publisher Copyright: {\textcopyright} 2017 American Cancer Society",

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doi = "10.1002/cncr.30667",

language = "English (US)",

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T2 - A global health crisis

AU - Small, William

AU - Bacon, Monica A.

AU - Bajaj, Amishi

AU - Chuang, Linus T.

AU - Fisher, Brandon J.

AU - Harkenrider, Matthew M.

AU - Jhingran, Anuja

AU - Kitchener, Henry C.

AU - Mileshkin, Linda R.

AU - Viswanathan, Akila N.

AU - Gaffney, David K.

PY - 2017/7/1

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N2 - Cervical cancer is the fourth most common malignancy diagnosed in women worldwide. Nearly all cases of cervical cancer result from infection with the human papillomavirus, and the prevention of cervical cancer includes screening and vaccination. Primary treatment options for patients with cervical cancer may include surgery or a concurrent chemoradiotherapy regimen consisting of cisplatin-based chemotherapy with external beam radiotherapy and brachytherapy. Cervical cancer causes more than one quarter of a million deaths per year as a result of grossly deficient treatments in many developing countries. This warrants a concerted global effort to counter the shocking loss of life and suffering that largely goes unreported. This article provides a review of the biology, prevention, and treatment of cervical cancer, and discusses the global cervical cancer crisis and efforts to improve the prevention and treatment of the disease in underdeveloped countries. Cancer 2017;123:2404–12.

AB - Cervical cancer is the fourth most common malignancy diagnosed in women worldwide. Nearly all cases of cervical cancer result from infection with the human papillomavirus, and the prevention of cervical cancer includes screening and vaccination. Primary treatment options for patients with cervical cancer may include surgery or a concurrent chemoradiotherapy regimen consisting of cisplatin-based chemotherapy with external beam radiotherapy and brachytherapy. Cervical cancer causes more than one quarter of a million deaths per year as a result of grossly deficient treatments in many developing countries. This warrants a concerted global effort to counter the shocking loss of life and suffering that largely goes unreported. This article provides a review of the biology, prevention, and treatment of cervical cancer, and discusses the global cervical cancer crisis and efforts to improve the prevention and treatment of the disease in underdeveloped countries. Cancer 2017;123:2404–12.

KW - Cervix Cancer Research Network (CCRN)

KW - Gynecological Cancer InterGroup (GCIG)

KW - activism

KW - brachytherapy

KW - cervical cancer

KW - chemotherapy

KW - developing world

KW - human papillomavirus (HPV)

KW - vaccination

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JO - Cancer

JF - Cancer

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ER -

Cervical cancer: A global health crisis

Abstract

Keywords

ASJC Scopus subject areas

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