Certainly can't live without this: SIRT6

Joseph T. Rodgers, Pere Puigserver

    Research output: Contribution to journalArticle

    Abstract

    Cellular metabolic rates might regulate aging by impinging on genomic stability through the DNA repair pathways. A new study published in Cell (Mostoslavsky et al., 2006) reports that deficiency in one of the mammalian Sir2 homologs, SIRT6, results in genome instability through the DNA base excision repair pathway and leads to aging-associated degenerative phenotypes.

    Original languageEnglish (US)
    Pages (from-to)77-78
    Number of pages2
    JournalCell Metabolism
    Volume3
    Issue number2
    DOIs
    StatePublished - Feb 2006

    ASJC Scopus subject areas

    • Cell Biology
    • Molecular Biology
    • Physiology

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