Cerenkov imaging

Sudeep Das, Jan Grimm, Daniel L J Thorek

Research output: Contribution to journalArticle

Abstract

Cerenkov luminescence (CL) has been used recently in a plethora of medical applications like imaging and therapy with clinically relevant medical isotopes. The range of medical isotopes used is fairly large and expanding. The generation of in vivo light is useful since it circumvents depth limitations for excitation light. Cerenkov luminescence imaging (CLI) is much cheaper in terms of infrastructure than positron emission tomography (PET) and is particularly useful for imaging of superficial structures. Imaging can basically be done using a sensitive camera optimized for low-light conditions, and it has a better resolution than any other nuclear imaging modality. CLI has been shown to effectively diagnose disease with regularly used PET isotope (18F-FDG) in clinical setting. Cerenkov luminescence tomography, Cerenkov luminescence endoscopy, and intraoperative Cerenkov imaging have also been explored with positive conclusions expanding the current range of applications. Cerenkov has also been used to improve PET imaging resolution since the source of both is the radioisotope being used. Smart imaging agents have been designed based on modulation of the Cerenkov signal using small molecules and nanoparticles giving better insight of the tumor biology.

Original languageEnglish (US)
Pages (from-to)213-234
Number of pages22
JournalAdvances in Cancer Research
Volume124
DOIs
StatePublished - 2014

Fingerprint

Luminescence
Isotopes
Positron-Emission Tomography
Light
Fluorodeoxyglucose F18
Radioisotopes
Nanoparticles
Endoscopy
Tomography
Neoplasms
Therapeutics

Keywords

  • Activatable
  • Cancer biology
  • Cerenkov luminescence
  • Clinical
  • Endoscopy
  • Fluorescence
  • Imaging
  • In vivo light
  • Intraoperative
  • Low-light camera
  • Nanoparticle
  • Positron emission
  • Quenching
  • SCIFI
  • Smart
  • Tomography

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Das, S., Grimm, J., & Thorek, D. L. J. (2014). Cerenkov imaging. Advances in Cancer Research, 124, 213-234. https://doi.org/10.1016/B978-0-12-411638-2.00006-9

Cerenkov imaging. / Das, Sudeep; Grimm, Jan; Thorek, Daniel L J.

In: Advances in Cancer Research, Vol. 124, 2014, p. 213-234.

Research output: Contribution to journalArticle

Das, S, Grimm, J & Thorek, DLJ 2014, 'Cerenkov imaging', Advances in Cancer Research, vol. 124, pp. 213-234. https://doi.org/10.1016/B978-0-12-411638-2.00006-9
Das, Sudeep ; Grimm, Jan ; Thorek, Daniel L J. / Cerenkov imaging. In: Advances in Cancer Research. 2014 ; Vol. 124. pp. 213-234.
@article{b42ac202f2874186b0568d49d100f485,
title = "Cerenkov imaging",
abstract = "Cerenkov luminescence (CL) has been used recently in a plethora of medical applications like imaging and therapy with clinically relevant medical isotopes. The range of medical isotopes used is fairly large and expanding. The generation of in vivo light is useful since it circumvents depth limitations for excitation light. Cerenkov luminescence imaging (CLI) is much cheaper in terms of infrastructure than positron emission tomography (PET) and is particularly useful for imaging of superficial structures. Imaging can basically be done using a sensitive camera optimized for low-light conditions, and it has a better resolution than any other nuclear imaging modality. CLI has been shown to effectively diagnose disease with regularly used PET isotope (18F-FDG) in clinical setting. Cerenkov luminescence tomography, Cerenkov luminescence endoscopy, and intraoperative Cerenkov imaging have also been explored with positive conclusions expanding the current range of applications. Cerenkov has also been used to improve PET imaging resolution since the source of both is the radioisotope being used. Smart imaging agents have been designed based on modulation of the Cerenkov signal using small molecules and nanoparticles giving better insight of the tumor biology.",
keywords = "Activatable, Cancer biology, Cerenkov luminescence, Clinical, Endoscopy, Fluorescence, Imaging, In vivo light, Intraoperative, Low-light camera, Nanoparticle, Positron emission, Quenching, SCIFI, Smart, Tomography",
author = "Sudeep Das and Jan Grimm and Thorek, {Daniel L J}",
year = "2014",
doi = "10.1016/B978-0-12-411638-2.00006-9",
language = "English (US)",
volume = "124",
pages = "213--234",
journal = "Advances in Cancer Research",
issn = "0065-230X",
publisher = "Academic Press Inc.",

}

TY - JOUR

T1 - Cerenkov imaging

AU - Das, Sudeep

AU - Grimm, Jan

AU - Thorek, Daniel L J

PY - 2014

Y1 - 2014

N2 - Cerenkov luminescence (CL) has been used recently in a plethora of medical applications like imaging and therapy with clinically relevant medical isotopes. The range of medical isotopes used is fairly large and expanding. The generation of in vivo light is useful since it circumvents depth limitations for excitation light. Cerenkov luminescence imaging (CLI) is much cheaper in terms of infrastructure than positron emission tomography (PET) and is particularly useful for imaging of superficial structures. Imaging can basically be done using a sensitive camera optimized for low-light conditions, and it has a better resolution than any other nuclear imaging modality. CLI has been shown to effectively diagnose disease with regularly used PET isotope (18F-FDG) in clinical setting. Cerenkov luminescence tomography, Cerenkov luminescence endoscopy, and intraoperative Cerenkov imaging have also been explored with positive conclusions expanding the current range of applications. Cerenkov has also been used to improve PET imaging resolution since the source of both is the radioisotope being used. Smart imaging agents have been designed based on modulation of the Cerenkov signal using small molecules and nanoparticles giving better insight of the tumor biology.

AB - Cerenkov luminescence (CL) has been used recently in a plethora of medical applications like imaging and therapy with clinically relevant medical isotopes. The range of medical isotopes used is fairly large and expanding. The generation of in vivo light is useful since it circumvents depth limitations for excitation light. Cerenkov luminescence imaging (CLI) is much cheaper in terms of infrastructure than positron emission tomography (PET) and is particularly useful for imaging of superficial structures. Imaging can basically be done using a sensitive camera optimized for low-light conditions, and it has a better resolution than any other nuclear imaging modality. CLI has been shown to effectively diagnose disease with regularly used PET isotope (18F-FDG) in clinical setting. Cerenkov luminescence tomography, Cerenkov luminescence endoscopy, and intraoperative Cerenkov imaging have also been explored with positive conclusions expanding the current range of applications. Cerenkov has also been used to improve PET imaging resolution since the source of both is the radioisotope being used. Smart imaging agents have been designed based on modulation of the Cerenkov signal using small molecules and nanoparticles giving better insight of the tumor biology.

KW - Activatable

KW - Cancer biology

KW - Cerenkov luminescence

KW - Clinical

KW - Endoscopy

KW - Fluorescence

KW - Imaging

KW - In vivo light

KW - Intraoperative

KW - Low-light camera

KW - Nanoparticle

KW - Positron emission

KW - Quenching

KW - SCIFI

KW - Smart

KW - Tomography

UR - http://www.scopus.com/inward/record.url?scp=84907851336&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84907851336&partnerID=8YFLogxK

U2 - 10.1016/B978-0-12-411638-2.00006-9

DO - 10.1016/B978-0-12-411638-2.00006-9

M3 - Article

VL - 124

SP - 213

EP - 234

JO - Advances in Cancer Research

JF - Advances in Cancer Research

SN - 0065-230X

ER -