Cerenkov imaging

Sudeep Das, Jan Grimm, Daniel L.J. Thorek

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Cerenkov luminescence (CL) has been used recently in a plethora of medical applications like imaging and therapy with clinically relevant medical isotopes. The range of medical isotopes used is fairly large and expanding. The generation of in vivo light is useful since it circumvents depth limitations for excitation light. Cerenkov luminescence imaging (CLI) is much cheaper in terms of infrastructure than positron emission tomography (PET) and is particularly useful for imaging of superficial structures. Imaging can basically be done using a sensitive camera optimized for low-light conditions, and it has a better resolution than any other nuclear imaging modality. CLI has been shown to effectively diagnose disease with regularly used PET isotope (18F-FDG) in clinical setting. Cerenkov luminescence tomography, Cerenkov luminescence endoscopy, and intraoperative Cerenkov imaging have also been explored with positive conclusions expanding the current range of applications. Cerenkov has also been used to improve PET imaging resolution since the source of both is the radioisotope being used. Smart imaging agents have been designed based on modulation of the Cerenkov signal using small molecules and nanoparticles giving better insight of the tumor biology.

Original languageEnglish (US)
Title of host publicationAdvances in Cancer Research
PublisherAcademic Press Inc.
Pages213-234
Number of pages22
DOIs
StatePublished - Jan 1 2014

Publication series

NameAdvances in Cancer Research
Volume124
ISSN (Print)0065-230X
ISSN (Electronic)2162-5557

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Keywords

  • Activatable
  • Cancer biology
  • Cerenkov luminescence
  • Clinical
  • Endoscopy
  • Fluorescence
  • Imaging
  • In vivo light
  • Intraoperative
  • Low-light camera
  • Nanoparticle
  • Positron emission
  • Quenching
  • SCIFI
  • Smart
  • Tomography

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Das, S., Grimm, J., & Thorek, D. L. J. (2014). Cerenkov imaging. In Advances in Cancer Research (pp. 213-234). (Advances in Cancer Research; Vol. 124). Academic Press Inc.. https://doi.org/10.1016/B978-0-12-411638-2.00006-9