Cerebrovascular risk factors and depression in older primary care patients

J. M. Lyness, E. D. Caine, D. A. King, Y. Conwell, Christopher Cox, P. R. Duberstein

Research output: Contribution to journalArticle


The authors examined whether cerebrovascular risk factors (CVRFs) are associated with depressive diagnoses and symptoms in 303 primary-care patients age ≥60 years, as would be consistent with a small-vessel brain disease model of later-life depression. CVRFs were not significantly independently associated with major, minor, or subsyndromal depression, late- onset major depression, or overall depressive symptom severity. These data did not support the notion that a small-vessel brain disease model of depression might apply to the majority of older persons with depressive symptoms and syndromes in primary-care settings. Future work should include longitudinal study with larger sample sizes.

Original languageEnglish (US)
Pages (from-to)252-258
Number of pages7
JournalAmerican Journal of Geriatric Psychiatry
Issue number3
Publication statusPublished - 1999
Externally publishedYes


ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Geriatrics and Gerontology

Cite this