Cerebrovascular risk factors and depression in older primary care patients: Testing a vascular brain disease model of depression

Jeffrey M. Lyness, Eric D. Caine, Deborah A. King, Yeates Conwell, Christopher Cox, Paul R. Duberstein

Research output: Contribution to journalArticlepeer-review

Abstract

The authors examined whether cerebrovascular risk factors (CVRFs) are associated with depressive diagnoses and symptoms in 303 primary-care patients age ≥60 years, as would be consistent with a small-vessel brain disease model of later-life depression. CVRFs were not significantly independently associated with major, minor, or subsyndromal depression, late-onset major depression, or overall depressive symptom severity. These data did not support the notion that a small-vessel brain disease model of depression might apply to the majority of older persons with depressive symptoms and syndromes in primary-care settings. Future work should include longitudinal study with larger sample sizes.

Original languageEnglish (US)
Pages (from-to)252-258
Number of pages7
JournalAmerican Journal of Geriatric Psychiatry
Volume7
Issue number3
DOIs
StatePublished - 1999
Externally publishedYes

ASJC Scopus subject areas

  • Geriatrics and Gerontology
  • Psychiatry and Mental health

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