TY - JOUR
T1 - Cerebrovascular responsiveness to CO2 in Haemophilus influenzae type b meningitis in rabbits
AU - Slater, A. J.
AU - Berkowitz, I. D.
AU - Wilson, D. A.
AU - Traystman, R. J.
N1 - Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 1994
Y1 - 1994
N2 - The effect of experimental meningitis on regional cerebral blood flow (rCBF), cerebral metabolic rate for oxygen (CMR(O2)), and cerebrovascular responsiveness to CO2 was determined in pentobarbital-anesthetized rabbits. The animals were inoculated intracisternally with saline (control) or log- phase Haemophilus influenzae type b (Hib). Eighteen hours later rCBF was determined with radiolabeled microspheres at normocapnia, hypocapnia, and hypercapnia. Cerebrovascular responses to hypocapnia and hypercapnia were assessed by calculating the change in cerebrovascular resistance per millimeter mercury change in Pa(CO2). At all CO2 levels, meningitis (M) was associated with elevated CBF compared with control (C: 47.5 ± 3.0, M: 60.9 ± 4.5 ml · 100 g-1 · min-1 at normocapnia, P < 0.01). Regional differences were present. In forebrain, the hyperemia in meningitis was confined to the superficial cortical grey matter. When compared with control, meningitis was not associated with altered vasoreactivity during hypocapnia (C: -0.026 ± 0.006, M: -0.026 ± 0.008 mmHg · ml-1 · 100 g-1 · min- 1 · mmHg Pa(CO2)/-1) or hypercapnia (C: -0.037 ± 0.004, M: -0.026 ± 0.008 mmHg · ml-1 · 100 g · min · mmHg Pa(CO2)/-1). CMR(O2) in meningitis was not significantly different from control (C: 3.53 ± 0.29, M: 3.51 ± 0.22 ml O2 · 100 g-1 · min-1). These findings indicate that cerebrovascular responsiveness to CO2 is preserved in experimental Hib meningitis. Furthermore, enhanced CBF together with unchanged CMR(O2) indicates that 'luxury' cerebral perfusion is present in this model of bacterial meningitis.
AB - The effect of experimental meningitis on regional cerebral blood flow (rCBF), cerebral metabolic rate for oxygen (CMR(O2)), and cerebrovascular responsiveness to CO2 was determined in pentobarbital-anesthetized rabbits. The animals were inoculated intracisternally with saline (control) or log- phase Haemophilus influenzae type b (Hib). Eighteen hours later rCBF was determined with radiolabeled microspheres at normocapnia, hypocapnia, and hypercapnia. Cerebrovascular responses to hypocapnia and hypercapnia were assessed by calculating the change in cerebrovascular resistance per millimeter mercury change in Pa(CO2). At all CO2 levels, meningitis (M) was associated with elevated CBF compared with control (C: 47.5 ± 3.0, M: 60.9 ± 4.5 ml · 100 g-1 · min-1 at normocapnia, P < 0.01). Regional differences were present. In forebrain, the hyperemia in meningitis was confined to the superficial cortical grey matter. When compared with control, meningitis was not associated with altered vasoreactivity during hypocapnia (C: -0.026 ± 0.006, M: -0.026 ± 0.008 mmHg · ml-1 · 100 g-1 · min- 1 · mmHg Pa(CO2)/-1) or hypercapnia (C: -0.037 ± 0.004, M: -0.026 ± 0.008 mmHg · ml-1 · 100 g · min · mmHg Pa(CO2)/-1). CMR(O2) in meningitis was not significantly different from control (C: 3.53 ± 0.29, M: 3.51 ± 0.22 ml O2 · 100 g-1 · min-1). These findings indicate that cerebrovascular responsiveness to CO2 is preserved in experimental Hib meningitis. Furthermore, enhanced CBF together with unchanged CMR(O2) indicates that 'luxury' cerebral perfusion is present in this model of bacterial meningitis.
KW - cerebral blood flow
KW - cerebral metabolic oxygen rate
KW - cerebral perfusion pressure
KW - hyperemia
KW - inflammation
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U2 - 10.1152/ajpheart.1994.266.5.h1755
DO - 10.1152/ajpheart.1994.266.5.h1755
M3 - Article
C2 - 8203576
AN - SCOPUS:0028438014
SN - 0363-6135
VL - 266
SP - H1755-H1761
JO - American Journal of Physiology - Heart and Circulatory Physiology
JF - American Journal of Physiology - Heart and Circulatory Physiology
IS - 5 35-5
ER -