Cerebrovascular responsiveness to CO2 in Haemophilus influenzae type b meningitis in rabbits

A. J. Slater, I. D. Berkowitz, D. A. Wilson, R. J. Traystman

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

The effect of experimental meningitis on regional cerebral blood flow (rCBF), cerebral metabolic rate for oxygen (CMR(O2)), and cerebrovascular responsiveness to CO2 was determined in pentobarbital-anesthetized rabbits. The animals were inoculated intracisternally with saline (control) or log- phase Haemophilus influenzae type b (Hib). Eighteen hours later rCBF was determined with radiolabeled microspheres at normocapnia, hypocapnia, and hypercapnia. Cerebrovascular responses to hypocapnia and hypercapnia were assessed by calculating the change in cerebrovascular resistance per millimeter mercury change in Pa(CO2). At all CO2 levels, meningitis (M) was associated with elevated CBF compared with control (C: 47.5 ± 3.0, M: 60.9 ± 4.5 ml · 100 g-1 · min-1 at normocapnia, P < 0.01). Regional differences were present. In forebrain, the hyperemia in meningitis was confined to the superficial cortical grey matter. When compared with control, meningitis was not associated with altered vasoreactivity during hypocapnia (C: -0.026 ± 0.006, M: -0.026 ± 0.008 mmHg · ml-1 · 100 g-1 · min- 1 · mmHg Pa(CO2)/-1) or hypercapnia (C: -0.037 ± 0.004, M: -0.026 ± 0.008 mmHg · ml-1 · 100 g · min · mmHg Pa(CO2)/-1). CMR(O2) in meningitis was not significantly different from control (C: 3.53 ± 0.29, M: 3.51 ± 0.22 ml O2 · 100 g-1 · min-1). These findings indicate that cerebrovascular responsiveness to CO2 is preserved in experimental Hib meningitis. Furthermore, enhanced CBF together with unchanged CMR(O2) indicates that 'luxury' cerebral perfusion is present in this model of bacterial meningitis.

Original languageEnglish (US)
Pages (from-to)H1755-H1761
JournalAmerican Journal of Physiology - Heart and Circulatory Physiology
Volume266
Issue number5 35-5
DOIs
StatePublished - 1994

Keywords

  • cerebral blood flow
  • cerebral metabolic oxygen rate
  • cerebral perfusion pressure
  • hyperemia
  • inflammation

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

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