Cerebrovascular effects of IV dopamine in fetal sheep

C. A. Gleason, R. Robinson, Andrew Harris, R. J. Traystman

Research output: Contribution to journalArticle

Abstract

Preterm newborns often receive IV dopamine to support their mean arterial blood pressure (MAP), but there is little data regarding their cerebrovascular responses. Using chronically-catheterized fetal sheep, we tested the hypothesis that IV dopamine causes dose-dependent cerebral vasoconstriction in immature fetuses. We measured cerebral blood flow (CBF-radiolabeled microspheres) and calculated cerebrovascular resistance (CVR) and cerebral O2 delivery (OD) in seven near-term ( 132 ± 1d) and eight preterm (93 ± 1d) fetal sheep, two days after catheter placement. Measurements were made at baseline and at four fetal dopamine infusion rates: 2.5, 7.5, 25 and 75 μg/kg/min. Results: (mean ± SEM)Rate Percent Change (compared to baseline) μg/kg/min MAP CBF CVR HR OD 93d 25 10 ± 2% No Δ 76 ± 51% 23 ± 3% No Δ 75 25 ± 5 No Δ 80 ± 33 21 ± 4 No Δ 132d 25 29 ± 4 No Δ 41 ± 12 No Δ No Δ 75 55 ± 3 No Δ 87 ± 23 No Δ No Δ Dopamine, at doses high enough to raise MAP at least 10% above baseline, causes cerebral vasoconstriction in both preterm and near term fetal sheep. This response could be detrimental to cerebral perfusion and O2 delivery, particularly during hypoxia/ischemia.

Original languageEnglish (US)
JournalFASEB Journal
Volume12
Issue number5
StatePublished - Mar 20 1998

Fingerprint

dopamine
Dopamine
Sheep
Blood pressure
Arterial Pressure
blood pressure
sheep
vasoconstriction
Vasoconstriction
Catheters
Cerebrovascular Circulation
dosage
ischemia
Microspheres
catheters
blood flow
fetus
hypoxia
neonates
Blood

ASJC Scopus subject areas

  • Agricultural and Biological Sciences (miscellaneous)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry
  • Cell Biology

Cite this

Gleason, C. A., Robinson, R., Harris, A., & Traystman, R. J. (1998). Cerebrovascular effects of IV dopamine in fetal sheep. FASEB Journal, 12(5).

Cerebrovascular effects of IV dopamine in fetal sheep. / Gleason, C. A.; Robinson, R.; Harris, Andrew; Traystman, R. J.

In: FASEB Journal, Vol. 12, No. 5, 20.03.1998.

Research output: Contribution to journalArticle

Gleason, CA, Robinson, R, Harris, A & Traystman, RJ 1998, 'Cerebrovascular effects of IV dopamine in fetal sheep', FASEB Journal, vol. 12, no. 5.
Gleason CA, Robinson R, Harris A, Traystman RJ. Cerebrovascular effects of IV dopamine in fetal sheep. FASEB Journal. 1998 Mar 20;12(5).
Gleason, C. A. ; Robinson, R. ; Harris, Andrew ; Traystman, R. J. / Cerebrovascular effects of IV dopamine in fetal sheep. In: FASEB Journal. 1998 ; Vol. 12, No. 5.
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