TY - JOUR
T1 - Cerebrovascular Disease and Cognitive Outcome in Patients with Cardiac Disease
AU - Johansen, Michelle C.
AU - Gottesman, Rebecca F.
N1 - Funding Information:
M.C.J. reports grants from American Heart Association and grants from NINDS, outside the submitted work.
Publisher Copyright:
© 2021. Thieme. All rights reserved. Thieme Medical Publishers, Inc..
PY - 2021/8/1
Y1 - 2021/8/1
N2 - The pace of understanding cognitive decline and dementia has rapidly accelerated over the past decade, with constantly evolving insights into the vascular contributions to cognitive impairment and dementia (VCID). Notably, more overlap has been discovered in the pathophysiology between what was previously understood to be Alzheimer's disease and VCID, leading to a heightened emphasis on disease prevention through early and aggressive control of vascular risk factors. One particularly vulnerable population may be those with cardiac disease, as they are at risk for cerebrovascular disease, which itself can lead to dementia, and increasing evidence supports cognitive impairment in disease processes such as heart failure and atrial fibrillation, independent of ischemic stroke, suggesting other potential mechanisms. In this article, we review the evidence supporting the relationship between cardiac disease, cerebrovascular disease, and cognitive decline and discuss the ongoing and future research efforts aimed at defining the important relationship between these entities.
AB - The pace of understanding cognitive decline and dementia has rapidly accelerated over the past decade, with constantly evolving insights into the vascular contributions to cognitive impairment and dementia (VCID). Notably, more overlap has been discovered in the pathophysiology between what was previously understood to be Alzheimer's disease and VCID, leading to a heightened emphasis on disease prevention through early and aggressive control of vascular risk factors. One particularly vulnerable population may be those with cardiac disease, as they are at risk for cerebrovascular disease, which itself can lead to dementia, and increasing evidence supports cognitive impairment in disease processes such as heart failure and atrial fibrillation, independent of ischemic stroke, suggesting other potential mechanisms. In this article, we review the evidence supporting the relationship between cardiac disease, cerebrovascular disease, and cognitive decline and discuss the ongoing and future research efforts aimed at defining the important relationship between these entities.
KW - cardiac disease
KW - cognition
KW - dementia
KW - infarct
KW - white matter disease
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U2 - 10.1055/s-0041-1726330
DO - 10.1055/s-0041-1726330
M3 - Article
C2 - 33851395
AN - SCOPUS:85104284939
SN - 0271-8235
VL - 41
SP - 463
EP - 472
JO - Seminars in neurology
JF - Seminars in neurology
IS - 4
ER -