Cerebrovascular compression in a canine model of obstructive hydrocephalus

Mark Luciano, D. J. Skarupa, A. M. Booth, M. J. Johnson, I. Ayznian, A. S. Wood, J. J. Hoegler

Research output: Contribution to journalArticle

Abstract

Because of observed cerebral blood flow changes in hydroceplialus, we hypothesised that there is a preferential compression of the cerebral vessels accompanying chronic tissue compression. In this preliminary study we quantitated 12 animals that underwent successful surgical induction of hydrocephalus via cyanoacrylic glue injection into the IVth ventricle. We investigated the degree and pattern of vascular compression by measuring the vessel density, diameter, and area percent in three serial sections from multiple regions m the parieto-occipital lobe. These parameters were related to the degree of tissue compression, as measured by post-induction .MR1. An overall increase in blood vessel area was observed in periventricular white matter (PW) (p = 0.036) and in superficial grey matter (p = 0.020). Vessel diameters were increased overall (p

Original languageEnglish (US)
Pages (from-to)53
Number of pages1
JournalEuropean Journal of Pediatric Surgery, Supplement
Volume9
Issue number1
StatePublished - 1999
Externally publishedYes

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Hydrocephalus
Blood Vessels
Canidae
Cerebrovascular Circulation
Occipital Lobe
Adhesives
Injections
White Matter
Gray Matter

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Luciano, M., Skarupa, D. J., Booth, A. M., Johnson, M. J., Ayznian, I., Wood, A. S., & Hoegler, J. J. (1999). Cerebrovascular compression in a canine model of obstructive hydrocephalus. European Journal of Pediatric Surgery, Supplement, 9(1), 53.

Cerebrovascular compression in a canine model of obstructive hydrocephalus. / Luciano, Mark; Skarupa, D. J.; Booth, A. M.; Johnson, M. J.; Ayznian, I.; Wood, A. S.; Hoegler, J. J.

In: European Journal of Pediatric Surgery, Supplement, Vol. 9, No. 1, 1999, p. 53.

Research output: Contribution to journalArticle

Luciano, M, Skarupa, DJ, Booth, AM, Johnson, MJ, Ayznian, I, Wood, AS & Hoegler, JJ 1999, 'Cerebrovascular compression in a canine model of obstructive hydrocephalus', European Journal of Pediatric Surgery, Supplement, vol. 9, no. 1, pp. 53.
Luciano, Mark ; Skarupa, D. J. ; Booth, A. M. ; Johnson, M. J. ; Ayznian, I. ; Wood, A. S. ; Hoegler, J. J. / Cerebrovascular compression in a canine model of obstructive hydrocephalus. In: European Journal of Pediatric Surgery, Supplement. 1999 ; Vol. 9, No. 1. pp. 53.
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